PCORI Funding Announcement: Accelerating Patient-Centered Outcomes Research and Methodological Research

January 7, 2013 by Joe Selby, MD, MPH

Joe.Selby_137X160A reminder that letters of intent (LOI) from researchers who intend to submit applications in response to the PCORI Funding Announcement (PFA) for Improving Methods for Conducting Patient-Centered Outcomes Research must be received by Tuesday, January 15, at 5:00 p.m. ET.

This PFA is designed to support research that addresses methodological gaps in patient-centered outcomes research (PCOR). PCORI expects to award $12 million for up to 14 contracts in this inaugural cycle. Additional PFAs to improve the nation’s underlying capacity to conduct PCOR rapidly, efficiently and consistently over time will be issued in the future.

This PFA corresponds to PCORI’s fifth priority area, Accelerating Patient-Centered and Methodological Research, from our National Priorities for Research and Research Agenda. The results of these studies will inform future iterations of PCORI’s methodology standards.

Our online Application Center provides the administrative guidelines and templates needed to complete your LOI. Submission of this letter through PCORI’s Online application system is required before submitting a full application. LOIs will not be scored. Consequently, no additional approval from PCORI is required prior to submitting a full application, unless your application is for more than $250,000 of direct costs in any given year or if your project exceeds three years. Additional details on the LOI requirements are provided in the PFA Application Guidelines. You can get more information through the quick links below.

Quick Links:

I certainly hope that if you’re interested in this opportunity to contribute to our critical work in improving methods for conducting PCOR that you’ll submit an LOI and then a full application, which is due March 13.

One Response to“PCORI Funding Announcement: Accelerating Patient-Centered Outcomes Research and Methodological Research”

  1. Davangere P Devanand

    I am thinking of analyzing data on the 10 functional items for instrumental activities of daily living in the Pfeffer Functional Activities Questionnaire across three databases: 1. National Alzheimer’s Centers Consortium which has approximately 16,000 patients, approximately half with Alzheimer’s disease and half with other dementias or mild cognitive impairment. 2. Alzheimer’s Disease Neuroimaging Initiative (ADNI) with 200 Alzheimer’s, 400 Mild Cognitive Impairment, and 200 cognitively intact controls. 3. My questionable dementia study with 150 patients with mild cognitive impairment and 63 controls.
    Each of these databases has follow-up of subjects from 3 years to 10 years. The research question is which of the 10 functional deficits on the scale best distinguish the three groups (Alzheimer’s mild cognitive impairment, controls) and which best predict conversion from mild cognitive impairment to Alzheimer’s disease. This has important clinical implications for mild to moderate memory loss if we can identify which functional deficits (e.g., financial errors in day-to-day living, making errors while cooking, forgetting to take medications) are indicators of early Alzheimer’s disease and which are not. The databases also have in common a large number of other key variables that are very comprehensive.
    These databases were all developed from patients who agreed to participate in research (primarily evaluation and follow-up, no treatment studies). Can these be proposed for analyses as I suggested for a PCORI grant application?

    Thank you.

    D.P. Devanand, M.D.
    Professor of Clinical Psychiatry and Neurology
    Columbia University


Leave a Reply