Notice of Upcoming Limited PCORI Funding Announcement (PFA)

Patient-Powered Research Networks (PPRNs) were funded by PCORI with the intent of supporting communities or networks of patients motivated to participate in clinical research through the National Patient-Centered Clinical Research Network (PCORnet) and to develop their capacity to govern the research activities of their networks. In this limited funding announcement for PPRNs, PCORI seeks to fund multiple high-quality clinical studies to answer important patient and stakeholder prioritized clinical effectiveness research (CER) questions that remain unanswered due to insufficient or inconclusive evidence. The three aims of this research PFA are to generate CER evidence relevant to specific conditions, treatments, and patient communities or more generally to clinical care for broader populations; to support PCORnet sustainability by attracting collaboration and support from non-PCORI funders in CER research; and to further development of data linkages between patient data and data from electronic health records and/or disease-specific registries. This is the next step in achieving a sustainable National research infrastructure that attracts a diverse set of public and private funders of research.

Applicants will be required to secure partner funding (which may include in-kind resources) from industry and/or organizational collaborators prior to submitting the full application. Preference will be given to applicants who secure at least 20% of total project cost from partner funding.

This PFA preannouncement is provided to allow potential applicants additional time to identify collaborators, obtain stakeholder input on the research question, and develop responsive, high-quality proposals.