Assessment of Prevention, Diagnosis, and Treatment Options – Winter 2014 Cycle


Letter of Intent Deadline:

October 15, 2013 by 5:00 .p.m (ET)


PCORI is seeking applications for comparative effectiveness research designed to provide information that would inform critical decisions that face patients and caregivers, clinicians, policy makers, and healthcare system leaders. These decisions must be consequential and be occurring now in the absence of sound evidence about the comparative effectiveness of alternative approaches. There must be substantial potential that patients/caregivers will benefit from the new knowledge in ways that are important to them. The premise of this research is that the new knowledge will inform critical choices by patients and stakeholders in health care. This knowledge will provide insight about the comparative benefits and harms of the options and provide information about outcomes that are important to patients.

Full Announcement:

Assessment of Prevention, Diagnosis, and Treatment Options

*Key Dates:

Online System Opens

September 16, 2013

Applicant Town Hall Session (Event webinar will be archived post event)

December 4; December 12

Letter of Intent (LOI) Due

October 15, 2013

Application Deadline

January 21, 2014 at 5:00 p.m. (ET)

Merit Review Dates

May 2014

Awards Announced

July 2014

Earliest Start Date

August 2014

Total Direct Costs:

$1.5 Million

Maximum Project Period:

3 Years

Funds Available Up To (Direct Costs):

$32 Million


Applications may be submitted by:

Any private sector research organization, including any:

  • Non-profit organization
  • For-profit organization

Any public sector research organization, including any:

  • University or college
  • Hospital or healthcare system
  • Laboratory or manufacturer
  • Unit of state or local government

All US applicant organizations must be recognized by the Internal Revenue Service. Foreign organizations and nondomestic components of organizations based in the United States may apply, as long as there is demonstrable benefit to the US healthcare system, and US efforts in the area of patient-centered research can be clearly shown. Organizations may submit multiple applications for funding. Individuals may not apply.

Review Criteria:

1. Impact of the condition on the health of individuals and populations

2. Potential for the study to improve health care and outcomes

3. Technical merit

4. Patient-centeredness

5. Patient and stakeholder engagement

Applicant Resources:

Application Guidelines


*Deadlines are at 5:00 PM ET. If deadlines fall on a weekend or a federal holiday, the deadline will be the following Monday or the next day after the federal holiday.

To propose a project budget that is greater than the direct costs or maximum project period listed for a PFA, submit a request by the LOI deadline using the templates provided above.

Note: We revised our application due dates as part of our transition from three to four funding cycles each year. Because of this transition, we extended the application due date for this PFA cycle from December 16, 2013 to January 21, 2014 at 5:00 p.m. (ET). We also renamed our cycles to align with our new schedule. As a result, this cycle, previously designated as our December 2013 cycle, was renamed the Winter 2014 Cycle with the new application deadline of January 21, 2014.