Assessment of Prevention, Diagnosis, and Treatment Options – Spring 2014 Cycle

Letter of Intent Deadline:

March 10, 2014 at 5:00 p.m. (ET)


PCORI is seeking applications for comparative effectiveness research designed to provide information that would inform critical decisions that face patients and caregivers, clinicians, policy makers, and health care system leaders. These decisions must be consequential and be occurring now in the absence of sound evidence about the comparative effectiveness of alternative approaches. There must be substantial potential that patients/caregivers will benefit from the new knowledge in ways that are important to them. The premise of this research is that the new knowledge will inform critical choices by patients and stakeholders in health care. This knowledge will provide insight about the comparative benefits and harms of the options and provide information about outcomes that are important to patients.

Full Announcement:

Assessment of Prevention, Diagnosis, and Treatment Options

*Key Dates:

Online System Opens

February 5, 2014

Applicant Town Hall Session

March 20, 2014

Letter of Intent (LOI) Due

March 10, 2014 at 5:00 pm ET

Application Deadline

May 6, 2014 at 5:00 pm ET

Merit Review Dates

August 2014

Awards Announced

September 2014

Earliest Start Date

December 2014

Total Direct Costs:

$2 Million

Maximum Project Period:

3 Years

Funds Available Up To:

$32 Million


Applications may be submitted by:

Any private sector research organization, including any:

  • Non-profit organization
  • For-profit organization

Any public sector research organization, including any:

  • University or college
  • Hospital or healthcare system
  • Laboratory or manufacturer
  • Unit of state or local government

All US applicant organizations must be recognized by the Internal Revenue Service. Foreign organizations and nondomestic components of organizations based in the United States may apply, as long as there is demonstrable benefit to the US healthcare system, and US efforts in the area of patient-centered research can be clearly shown. Organizations may submit multiple applications for funding. Individuals may not apply.

Review Criteria:

1. Impact of the condition on the health of individuals and populations

2. Potential for the study to improve health care and outcomes

3. Technical merit

4. Patient-centeredness

5. Patient and stakeholder engagement

Applicant Resources:

Applicant FAQs

Application Checklist

PCORI Application Guidelines

Budget Justification Template

Budget Summary for the Entire Project Template

Detailed Budget Template

Engagement Template

Methodology Report and Standards

People and Places Template

PCORI Funded Projects: Sample Engagement Plans

PCORI Online System

PCORI Online System User Manual: Submitting a Letter of Intent

PCORI Online System User Manual: Submitting an Application

PCORI Policy on Submission of Research Contract Applications

Research Plan Template

Sample Contract for Funded Research Projects

Technical Abstract Worksheet


*Deadlines are at 5:00 PM ET. If deadlines fall on a weekend or a federal holiday, the deadline will be the following Monday or the next day after the federal holiday.