The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved $34 million to fund three large comparative clinical effectiveness research (CER) studies and research to enhance the methods for conducting CER. The funds will support studies of a range of conditions and problems that impose high burdens on patients, caregivers and the healthcare system.
The Patient-Centered Outcomes Research Institute (PCORI) has issued nine new announcements offering up to a total of $200 million in funding for studies comparing which different healthcare options work most effectively for which patients across a range of conditions.
Learn more about our work, the research we fund, and our programs and initiatives.
PCORI's Research Funding
Find out what type of research PCORI supports and what we have funded.
Research Done Differently
We're committed to a new approach to health research. Learn how it’s different.
Better Research Through Engagement
Find out what we mean by engagement, how PCORI engages patients and other healthcare stakeholders, and how we encourage others to do so.
Targeted Funding Announcements
Learn more about our research on specific, high-priority topics likely to have a substantial impact on practice and patient outcomes.
Pragmatic Clinical Studies Initiative
Learn more about this funding opportunity aimed at comparing outcomes of two or more interventions to healthcare issues faced by patients.
Dissemination & Implementation
Read how we’re speeding up the process of getting the word out on results from our funded projects.
PCORI’s initiative to evaluate all relevant completed studies on a question or topic to clarify what is known and what evidence gaps need to be filled.
PCORI’s Milestones at Age 6
An overview of our milestones since being created in the fall of 2010.
The PCORI Application Process
Learn how to apply for PCORI funding, with listings of applicant resources, frequently asked questions, and keys for success.
Become a PCORI Peer Reviewer
We encourage interested patients, caregivers, clinicians, researchers, and other healthcare stakeholders to sign on to become Peer Reviewers. We want to ensure that research studies funded by PCORI are held to the highest standards of scientific integrity and usefulness to stakeholders.
Help Wanted - PCORI Reviewers
We invite patients, scientists, and other healthcare stakeholders to help us review applications for funding.
Why Methods Matter
See how we are supporting development and use of best methods for patient-centered outcomes research.
PCORnet - the National Patient-Centered Clinical Research Network
Learn what networks are part of this coalition and how it will support clinical research.
PCORnet’s First Observational Studies
Find out more about research to address questions on the treatment and prevention of obesity.
The PCORnet ADAPTABLE Aspirin Study
Read about this study that will help determine the best dose of aspirin to use to prevent heart attacks and strokes in people with heart disease.
Funded Research Snapshots
Read examples of our patient-centered comparative research in action.
Learn about high-priority topics in our research portfolio.
Posted: September 30, 2014; Updated: February 8, 2017
This collection of articles and opinion pieces provides insights into PCORI’s work to advance patient-centered comparative clinical effectiveness research. The collection includes papers, articles, and commentaries written by researchers working on PCORI-funded projects and by PCORI staff, members of our Board of Governors and Methodology Committee, and others who are following our work.
PCORI is committed to the principle of transparency and openness in all of our work, including the sharing of information about our activities and the dissemination of research findings. We encourage authors to make their articles available without a subscription. In the pages below, we provide links when articles are available without charge.
Annals of Family Medicine
Saver BG., Mazor KM, Luckman R, Cutrona SL, Hayes M, et al. Persuasive Interventions for Controversial Cancer Screening Recommendations: Testing a Novel Approach to Help Patients Make Evidence-Based Decisions. Ann Fam Med 2017;15:48-55. DOI: 10.1370/afm.1996.
More about this study
BMC Medical Informatics & Decision Making
Dugas M, Trottier MÈ, Chipenda Dansokho S, Vaisson G, Provencher T, Colquhoun H, Dogba MJ, Dupéré S, Fagerlin A, Giguere AM, Haslett L, Hoffman AS, Ivers NM, Légaré F, Légaré J, Levin CA, Menear M, Renaud JS, Stacey D, Volk RJ, Witteman HO. Involving members of vulnerable populations in the development of patient decision aids: a mixed methods sequential explanatory study. BMC Med Inform Decis Mak. 2017 Jan 19;17(1):12. doi: 10.1186/s12911-016-0399-8. PubMed PMID: 28103862.
More about this study
Health Expectations Journal
Pérez Jolles M, Martinez M, Garcia SJ, Stein GL, Mentor Parent Group Members, Thomas KC. Involving Latina/o parents in patient-centered outcomes research: Contributions to research study design, implementation and outcomes. Health Expect. 2017 Feb 8. doi: 10.1111/hex.12540. [Epub ahead of print] PubMed PMID: 28177564.
More about this study
Annals of Family Medicine
Sheridan S, Schrandt S, Forsythe L, Hilliard TS, Paez KA. The PCORI Engagement Rubric: Promising Practices for Partnering in Research. Ann Fam Med. March/April 2017 15:165-170; doi:10.1370/afm.2042.
Annals of Internal Medicine
Bibbins-Domingo K, Whitlock E, Wolff T, Ngo-Metzger Q, Phillips WR, Davidson KW, Krist AH, Lin JS, Mangione CM, Kurth AE, García FA, Curry SJ, Grossman DC, Landefeld CS, Epling JW Jr, Siu AL. Developing Recommendations for Evidence-Based Clinical Preventive Services for Diverse Populations: Methods of the U.S. Preventive Services Task Force. Ann Intern Med. 2017 Mar 7. doi:10.7326/M16-2656. [Epub ahead of print] PubMed PMID: 28265649.
Journal of Comparative Effectiveness Research
Forsythe LP, Frank LB, Workman TA, Hilliard T, Harwell D, Fayish L. Patient, caregiver and clinician views on engagement in comparative effectiveness research. J Comp Eff Res. 2017 Feb 8. doi: 10.2217/cer-2016-0062. [Epub ahead of print] PubMed PMID: 28173732.
Rehabilitation Nursing Journal
Black T, Vital, C. Changing the Research Landscape. Rehab Nurs J. 2017;42(2):55-57. doi: 10.1097/RNJ.0000000000000037. Editorial.
Mazur S, Bazemore A, Merenstein D. Characteristics of Early Recipients of Patient-Centered Outcomes Research Institute Funding. Acad Med. 2016 Feb 9. [Epub ahead of print] PubMed PMID: 26862840.
eGEMs (Generating Evidence & Methods to improve patient outcomes)
Haynes K, Selvam N, Cziraky MJ. Bidirectional Data Collaborations in Distributed Research. EGEMS (Wash DC). 2016 Mar 22;4(2):1205. doi: 10.13063/2327-9214.1205. eCollection 2016. PubMed PMID: 27141518; PubMed Central PMCID: PMC4827790.
Carman KL, Maurer M, Mangrum R, Yang M, Ginsburg M, Sofaer S, et al. Understanding An Informed Public’s Views On The Role Of Evidence In Making Health Care Decisions. Health Affairs 2016 April 01;35(4):566-574.
Weil A R. The Patient Engagement Imperative. Health Affairs 2016 April 01;35(4):744-745.
Posted: March 5, 2014; Updated: March 17, 2017