The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved the development of two new PCORI Funding Announcements (PFAs) that together will offer up to $41 million in support of comparative clinical effectiveness research (CER).
The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today adopted the newest version of the PCORI Methodology Standards. The updates include new standards on analysis of clustered data, inclusion of a formal study protocol in public data, and approaches to selection and usage of data networks, among other changes.
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Funded Research Snapshots
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Posted: September 30, 2014; Updated: June 16, 2017
This collection of papers, articles, and commentaries provides insights into PCORI-funded work to advance patient-centered comparative clinical effectiveness research. PCORI is committed to the principles of transparency and openness in all of our work. We encourage authors to make their publications available without a subscription.
Men who had their prostate cancer treated with either the latest forms of surgery or radiation therapy experienced greater rates of problems, either urinary, bowel or sexual, during the first several months afterward as compared to those who opted to wait and closely monitor their cancer. However, the outcomes among all groups were similar after two years, according to findings published in the Journal of the American Medical Association from a study led by Ronald Chen.
Surgery to treat prostate cancer, including robot-assisted procedures, was associated with greater rates of incontinence and sexual problems than either external beam radiation or watchful waiting even three years afterward. But surgery also resulted in fewer other urinary symptoms than active surveillance, according to findings published in the Journal of the American Medical Association from a study led by David Penson.
As part of their larger study David Nelson and colleagues conducted a systematic review of 42 published studies of new drugs for hepatitis C infections. As they reported in the Annals of Internal Medicine they found all the treatment regimens to be highly effective and well-tolerated in general. However, they saw some variation in outcomes linked to particular type of virus and patient characteristics such as having other conditions such as chronic kidney disease or HIV.
Including family members of hospitalized patients in the effort to report medical errors and adverse events increased the capture of such errors by 16 percent and capture of adverse events by 10 percent, according to findings in JAMA Pediatrics. The findings stem from a study led by Christopher Landrigan.
Posted: March 5, 2014; Updated: April 20, 2017