The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved $14.8 million to fund a study of two newer blood-thinning medications. The study will compare the two drugs against each other and against the older drug warfarin to see which works best in preventing the recurrence of dangerous blood clots in the veins and lungs.
The Patient-Centered Outcomes Research Institute (PCORI) this week welcomes two new Board of Governors members—Russell Howerton, MD, Chief Medical Officer and Vice President of Clinical Operations at Wake Forest Baptist Medical Center, and Kathleen Troeger, MPH, Director of Outcomes Research at Hologic, Inc.
PCORI welcomes you to learn more about research we fund, our programs and initiatives. In an effort to better understand our work, we have provided a list of fact sheets below that are available for you to download and print.
PCORI's Research Funding
Find out what type of research PCORI supports and what we have funded.
Research Done Differently
We're committed to a new approach to health research. Learn how it’s different.
Better Research Through Engagement
Find out what we mean by engagement, how PCORI engages patients and other healthcare stakeholders, and how we encourage others to do so.
Targeted Funding Announcements
Learn more about our research on specific, high-priority topics likely to have a substantial impact on practice and patient outcomes.
Pragmatic Clinical Studies Initiative
Learn more about this funding opportunity aimed at comparing outcomes of two or more interventions to healthcare issues faced by patients.
PCORnet - the National Patient-Centered Clinical Research Network
Learn what networks are part of this coalition and how it will support clinical research.
PCORnet’s First Observational Studies
Find out more about research to address questions on the treatment and prevention of obesity.
The PCORnet ADAPTABLE Aspirin Study
Read about this study that will help determine the best dose of aspirin to use to prevent heart attacks and strokes in people with heart disease.
Snapshots of PCORI Research on Specific Topics
Learn about our research portfolio’s focus on high-priority topics.
PCORI-Funded Research on Addressing Healthcare Disparities
Find out more about our work to reduce healthcare disparities among different subpopulations.
PCORI-Funded Research on Arthritis
We currently support more than a dozen patient-centered comparative clinical effectiveness research (CER) studies and methods projects related to arthritis
PCORI-Funded Research on Cancer
Read about our portfolio addressing cancer, the second leading cause of death in the United States.
PCORI-Funded Research on Cardiovascular Disease
Learn about our research on heart disease, which remains the leading cause of death nationally.
PCORI-Funded Research on Chronic Pain and Opioids
Read about our projects on managing chronic pain and addressing opioid use.
PCORI-Funded Research on Dementia and Cognitive Impairment
Our studies on dementia and cognitive impairment are more important than ever as older adults continue to make up a larger part of the nation’s population.
PCORI-Funded Research on Mental Health
Around one-fifth of American adults suffer from mental illness. Learn how we’re studying ways to deal with depression, anxiety, and other mental health issues.
PCORI-Funded Research on Obesity
Obesity trails only tobacco on the list of causes of preventable death in the United States. Learn more about our projects focusing on obesity.
PCORI-Funded Research on Rare Disease
PCORI recognizes the special challenges that rare diseases, which often are understudied, pose. Learn more about our growing research portfolio.
PCORI-Funded Research on Shared Decision Making
Learn about the studies that compare healthcare options to produce evidence to help patients and those who care for them make better-informed decisions.
Take a look at our milestones, beginning in 2010, related to research, engagement, and leadership.
Funded Research Snapshots
Read examples of our patient-centered comparative research in action.
The PCORI Application Process
Learn how to apply for PCORI funding, with listings of applicant resources, frequently asked questions, and keys for success.
Help Wanted - PCORI Reviewers
We invite patients, scientists, and other healthcare stakeholders to help us review applications for funding.
Why Methods Matter
See how we are supporting development and use of best methods for patient-centered outcomes research.
Posted: September 30, 2014; Updated: August 17, 2016
This collection of articles and opinion pieces provides insights into PCORI’s work to advance patient-centered comparative clinical effectiveness research. The collection includes papers, articles, and commentaries written by researchers working on PCORI-funded projects and by PCORI staff, members of our Board of Governors and Methodology Committee, and others who are following our work.
PCORI is committed to the principle of transparency and openness in all of our work, including the sharing of information about our activities and the dissemination of research findings. We encourage authors to make their articles available without a subscription. In the pages below, we provide links when articles are available without charge.
Journal of Oncology Practice
Osarogiagbon RU. Overcoming the Implementation Gap in Multidisciplinary Oncology Care Programs. J Oncol Pract. 2016 Aug 16. pii: JOPR014688. [Epub ahead of print] PubMed PMID: 27531378. (Abstract only available)
More about this study
Therapeutic Innovation & Regulatory Science
Meredith Y. Smith, Tarek A. Hammad, Marilyn Metcalf, Bennett Levitan, Rebecca Noel, Anne M. Wolka, Debra L. Michaels, and F. Reed Johnson. Patient Engagement at a Tipping Point— The Need for Cultural Change Across Patient, Sponsor, and Regulator Stakeholders: Insights From the DIA Conference, ‘‘Patient Engagement in Benefit Risk Assessment Throughout the Life Cycle of Medical Products. Therapeutic Innovation & Regulatory Science September 2016 vol. 50 no. 5 546-553.
More about this study
The Journal of Surgical Research
Lau BD, Streiff MB, Hobson DB, Kraus PS, Shaffer DL, Popoola VO, Farrow NE, Efron DT, Haut ER. Beneficial "halo effects" of surgical resident performance feedback. J Surg Res. 2016 Sep;205(1):179-85. doi: 10.1016/j.jss.2016.06.024. Epub 2016 Jun 15. PubMed PMID: 27621016. (Abstract only available)
More about this study
Academic Emergency Medicine
Kanzaria HK, Booker-Vaughns J, Itakura K, Yadav K, Kane B, Gayer C, Lin G, LeBlanc A, Gibson R, Chen E, Williams P, Carpenter CR. Dissemination and Implementation of Shared Decision-Making into Clinical Practice: A Research Agenda. Acad Emerg Med. 2016 Aug 26. doi: 10.1111/acem.13075. [Epub ahead of print] PubMed PMID: 27561951. (Abstract only available)
Annals of Internal Medicine
Selby JV. Complementary Efforts Make for Efficient Research. Ann Intern Med. 2016 Apr 26. doi: 10.7326/M16-0869. [Epub ahead of print] PubMed PMID: 27110867. (Abstract only available)
BMC Health Services Research
Walker KO, Stewart AL, Grumbach K. Development of a survey instrument to measure patient experience of integrated care. BMC Health Serv Res. 2016 Jun 1;16(1):193. doi: 10.1186/s12913-016-1437-z. PubMed PMID: 27250117; PubMed Central PMCID: PMC4890282.
Journal of Cancer Education
Finney Rutten LJ, Agunwamba AA, Wilson P, Chawla N, Vieux S, Blanch-Hartigan D, Arora NK, Blake K, Hesse BW.Cancer-Related Information Seeking Among Cancer Survivors: Trends Over a Decade (2003-2013). J Cancer Educ. 2016 Jun;31(2):348-57. doi: 10.1007/s13187-015-0802-7. PubMed PMID: 25712202. (Abstract only available)
Journal of Cancer Survivorship
O'Malley D, Hudson SV, Nekhlyudov L, Howard J, Rubinstein E, Lee HS, Overholser LS, Shaw A, Givens S, Burton JS, Grunfeld E, Parry C, Crabtree BF. Learning the landscape: implementation challenges of primary care innovators around cancer survivorship care. J Cancer Surviv. 2016 Jun 8. [Epub ahead of print] PubMed PMID: 27277895. (Abstract only available)
Journal of Comparative Effectiveness Research
Gayer CC, Crowley MJ, Lawrence WF, Gierisch JM, Gaglio B, Williams JW Jr, Myers ER, Kendrick A, Slutsky J, Sanders GD. An overview and discussion of the Patient-Centered Outcomes Research Institute's decision aid portfolio. J Comp EffRes. 2016 Jun 14. [Epub ahead of print] PubMed PMID: 27298206.
Journal of Oncology Practice
Tisnado D, Malin J, Kahn K, Landrum MB, Fletcher R, Klabunde C, Clauser S, Rogers SO Jr, Keating NL. Variations in Oncologist Recommendations for Chemotherapy for Stage IV Lung Cancer: What Is the Role of Performance Status? J Oncol Pract. 2016 Jun 7. pii: JOPR008425. [Epub ahead of print] PubMed PMID: 27271507 (Abstract only available)
Metabolic Brain Disease
Bajaj JS, Frederick RT, Bass NM, Ghabril M, Coyne K, Margolis MK, Santoro M, Coakley DF, Mokhtarani M, Jurek M, Scharschmidt BF. Overt hepatic encephalopathy: development of a novel clinician reported outcome tool and electronic caregiver diary. Metab Brain Dis. 2016 Jun 9. [Epub ahead of print] PubMed PMID: 27278222. (View abstract only)
Mazur S, Bazemore A, Merenstein D. Characteristics of Early Recipients of Patient-Centered Outcomes Research Institute Funding. Acad Med. 2016 Feb 9. [Epub ahead of print] PubMed PMID: 26862840.
eGEMs (Generating Evidence & Methods to improve patient outcomes)
Haynes K, Selvam N, Cziraky MJ. Bidirectional Data Collaborations in Distributed Research. EGEMS (Wash DC). 2016 Mar 22;4(2):1205. doi: 10.13063/2327-9214.1205. eCollection 2016. PubMed PMID: 27141518; PubMed Central PMCID: PMC4827790.
Carman KL, Maurer M, Mangrum R, Yang M, Ginsburg M, Sofaer S, et al. Understanding An Informed Public’s Views On The Role Of Evidence In Making Health Care Decisions. Health Affairs 2016 April 01;35(4):566-574.
Weil A R. The Patient Engagement Imperative. Health Affairs 2016 April 01;35(4):744-745.
Posted: March 5, 2014; Updated: September 14, 2016