What & Who We Fund

Research Focus

Comparative Clinical Effectiveness Research (CER)

Studies that improve health or health care outcomes, including risks and benefits, of two or more approaches to health care

CER Methods and Infrastructure

Studies to improve the methods available for patient-centered CER  

Development of a large, highly representative electronic-data infrastructure called PCORnet^®, The National Patient-Centered Clinical Research Network, for improving the conduct of patient-centered CER

Research Focus Areas

PCORI’s Research Project Agenda includes a set of broad Topic Themes, approved by PCORI’s Board of Governors in July 2022, as well as ongoing topics—preventing maternal morbidity and mortality, improving outcomes for people with intellectual or developmental disabilities (IDD), addressing COVID-19, and addressing rare disease. The broad Topic Themes speak to health issues facing large numbers of people in the United States including children, youth, and older adults and address urgent topics such as violence and trauma, substance use, and mental and behavioral health, as well as widespread conditions including cardiovascular disease, pain management, and sleep health. 

Eligibility

Private Sector

Public Sector

US Organizations

Must be recognized by the Internal Revenue Service

Foreign Organizations and Nondomestic Components of US Organizations

Foreign organizations and nondomestic components of US organizations must provide a thorough and thoughtful justification for the research’s ability to benefit the US healthcare system and must show that the engagement plans include US patients and stakeholders and are relevant to the US healthcare system.

Individuals

Not permitted to apply

Posted: September 2014; Updated: July 2023