Request for Information: Draft Translation Table Framework

The Methodology Committee of PCORI was established to develop and improve the science and methods of comparative clinical effectiveness research. The legislation calls on the Methodology Committee to develop “a translation table that is designed to provide guidance and act as a reference for the Board to determine research methods that are most likely to address each specific comparative clinical effectiveness research question,” and to produce a report by May 2012 outlining the progress on the development of this translation table. The Methodology Committee has developed a preliminary translation framework that will inform the development of the translation table.

PCORI has issued this Request for Information (RFI) to invite input on the translation framework components and to engage stakeholder communities in the development of PCORI’s translation tool.

Responses to this RFI must be submitted electronically no later than February 17, 2012 at 5:00 PM ET.

INFORMATION REQUESTED

PCORI seeks suggestions for the improvement of the draft framework components, thoughts on alternate components or frameworks, discussion of how these components apply to different research domains, and comments on the limitations of the proposed framework.

To fully explain and illustrate input and comments submitted, we encourage respondents to provide specific examples or case studies based on patient-centered research questions. Case studies should briefly describe the research question of interest and demonstrate application of the translation framework. The decisions about the design and methods used in patient-centered outcomes research require consideration of the tradeoffs in applying each translation framework component. Authors of case studies should discuss these decisions/tradeoffs from the perspective of at least one potential decision-maker or stakeholder.

We are not seeking case studies on how to develop patient-centered research questions but rather, discussion of the tradeoffs between designs one would make based on preferences on the relative importance of framework components. For example, for a research question involving use of a new medical device, one would discuss the different designs that would be most appropriate/ inappropriate based on prior evidence in this area and the relative importance of framework components (e.g., time urgency, precision, subgroup effects) to the decision-maker.

Case studies based on patient-centered research questions and supported by references and other documentation have the greatest chance of being used in the report.

Responses to this RFI will be considered for inclusion in the May 2012 report. Authors of case studies chosen for inclusion in the published report or of suggestions that result in qualitative modification of the framework will be publically acknowledged.

Request for Information:Draft Translation Table Framework (PDF)

Provide Information/Feedback on Draft Translation Table Framework

Questions about this RFI? Please email RMWG@pcori.org.

 

Responses to this RFI must be submitted electronically to http://www.pcori.org/provide-input/translation-table/provide-information/no later than February 17, 2012 at 5:00 PM ET.