Finding the Keys to a Longer, Better Life after Stroke
Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER)
Adrian F. Hernandez, MD, MHS
Goal: Using new and existing data on the risks and benefits of anticoagulant, statin, and antidepressant therapy to develop a tool that will help poststroke patients choose treatment best suited to their individual characteristics and preferences.
DURHAM, NC—Every year, around 800,000 people in the United States have a stroke, and many end up disabled or needing additional medical care. What’s more, about one-quarter of patients who’ve had one stroke have a recurrence, so doctors often prescribe one or more additional therapies to prevent later strokes. Although there have been previous studies on such medications, better evidence is needed about which ones work best for which patients.
“Every day, patients who leave the hospital after a stroke are uncertain about the right treatment for their individual case,” says Adrian F. Hernandez, MD, MHS, a cardiologist at Duke University and the Duke Clinical Research Institute.
Data are particularly scant for certain types of patients, Hernandez says, including older people, women, and members of racial and ethnic minorities. In addition, previous research has tended to overlook some outcomes patients care about strongly, such as mood, energy levels, and the ability to work.
“There’s not enough information available to providers or patients about what’s really important in recovery,” says Lesley Maisch of Buffalo, New York, who had a stroke seven years ago. In a PCORI-funded project that aims to fill some of the gaps, patients’ input convinced researchers to focus on an outcome that they hadn’t previously considered.
A Wealth of Data
To learn which treatments work best for which patients after a stroke, the Duke research team is taking advantage of information already collected on the nearly half a million people who were treated for stroke at 190 hospitals between 2003 and 2012. The analysis will also include reports on disability, depression, and quality of life provided by telephone interviews of 3,000 of the patients in the database. Information that’s more detailed will come from a survey of 2,000 additional stroke patients. The study is called the PROSPER (Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research) project.
The research team, which includes Hernandez as the Principal Investigator and Maisch as a patient partner, is looking closely at three types of treatments commonly prescribed after stroke. One is blood thinners, or anticoagulants, intended to help prevent another stroke. In the study, the widely used drug warfarin goes head-to-head with newer anticoagulant medications that have not been investigated as thoroughly.
Cholesterol-lowering drugs (called statins) are also prescribed to prevent future strokes. The research team is evaluating benefits and side effects of various doses.
Doctors also may prescribe antidepressants because depression is common among stroke survivors, and research has linked it to higher mortality. The research team is examining whether these medications improve length and quality of life.
Analyzing data previously collected during medical care, as PROSPER is doing, may not give the same results as carefully controlled clinical trials do, Hernandez says. But the results could be more applicable and relevant to a broad array of patients, including older people who are likely to have medical problems in addition to stroke. Many stroke patients have other conditions, but clinical trials often exclude such patients.
“Patients were involved in the project from the outset,” Hernandez says. Because of patients’ perspectives, the research team made a fundamental change in which treatments to test. “Beforehand, the clinical investigators had been interested in clot-busting drugs used at the time of stroke, but when we spoke with patients, concern about poststroke depression came up more,” Hernandez says. So, the study looks at antidepressants.
Three patients, including Maisch, became members of the study’s steering committee, helping develop the proposal and subsequent study.
Through focus groups, the researcher team realized that patients place particular importance on “home time”—the number of days they spend out of the hospital, Hernandez says. This measure reflects quality of life, length of survival, and recurrence of stroke. The research team is measuring home time as its primary outcome in evaluating all three types of treatment.
Hernandez first asked Maisch to take a leading role in PROSPER after she participated in the survey. Maisch recalls, “I jumped at the chance because I felt more information on stroke needs to be available for patients and for doctors. But then I thought, ‘What can I contribute? I’m just a secretary.’”
She adds, “When I met with the doctors at Duke about the survey, and they seemed so excited to get my feedback, and were so encouraging, I felt blessed to be part of it.”
Results of the study have begun to emerge. The team has published articles on the risks and benefits of statins and warfarin. For example, compared with patients who did not get a statin prescription after stroke, those who took statins experienced 28 more days of home time over two years. The research team found similar outcomes for patients on higher doses and lower doses of the statins.
In the case of warfarin, a study of stroke patients who also had a heart rate problem called atrial fibrillation found a benefit to the medicine. Those who received a warfarin prescription averaged 48 more days of home time over two years than those who did not receive the prescription. Warfarin was beneficial for a wide variety of participants, including women, patients older than 80, those who had the most severe strokes, and patients with additional medical problems.
The ultimate aim of PROSPER is to funnel findings into tools that will help patients and caregivers make informed decisions about treatment and self-care, based on individual characteristics, values, preferences, and needs.
Posted: December 21, 2015