This collection of various publications—papers, articles, and commentaries—provides insights into PCORI’s work to advance patient-centered comparative clinical effectiveness research.
Findings Help Men Choose Among Prostate Cancer Treatment Options
Findings from two studies published in JAMA comparing contemporary treatment options for prostate cancer provide men additional evidence to help them choose which is best for them. The studies led by David Penson and Ronald Chen each found greater rates of urinary, bowel, and sexual problems among those who had one of the active treatments than those who opted to wait and watch. However, the outcomes among all groups were similar after two years.
Association Between Choice of Radical Prostatectomy, External Beam Radiotherapy, Brachytherapy, or Active Surveillance and Patient-Reported Quality of Life Among Men With Localized Prostate Cancer, JAMA
Systematic Review of Hepatitis C Drug Studies
As part of their larger study, David Nelson and colleagues conducted a systematic review of 42 published studies of new drugs for hepatitis C infections. They found the treatment regimens to be highly effective in general, but some people, such as those with chronic kidney disease, experienced slightly lower virus remission rates and to have more difficulty tolerating the drugs.
Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review, Annals of Internal Medicine
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These publications have been written by researchers working on PCORI-funded projects and by PCORI staff, members of our Board of Governors and Methodology Committee, and others who are following our work.
PCORI is committed to the principle of transparency and openness in all of our work, including the sharing of information about our activities and the dissemination of research findings. We encourage authors to make their publications available without a subscription.
Posted: March 5, 2014; Updated: March 29, 2017