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Treatment-Resistant Depression Major depressive disorder is a serious health concern for adults in the United States. According to data from the Centers for Disease Control and Prevention, close to one…

PCORI’s mandate is to improve the quality and relevance of evidence that can help patients, caregivers, clinicians and others make better-informed health or healthcare decisions. Our Evidence Updates are one…

What is peripartum depression? Peripartum depression is more than just “baby blues:” this condition is clinical depression experienced by a person during pregnancy or after giving birth that can continue…

Mental health conditions impact individuals across age, income, racial, and ethnic groups. One in five people in the United States will experience a mental health condition within a given year…

The Eugene Washington PCORI Engagement Award Program is now accepting applications for the October 2023 Cycle PCORI Funding Announcements (PFAs). The Engagement Award Program supports projects that encourage active, meaningful…

About this Blog Series Kristin Lee Berg, PhD, LCSW, was never a rebellious teenager, but she did have to navigate total vision loss in one eye and partial blindness in…

Editor's Note (February 27, 2023) These eight Topic Themes join four that are ongoing—preventing maternal morbidity and mortality, improving outcomes for people with intellectual or developmental disabilities, addressing COVID-19, and…

About this Blog Series On March 10, 2020, the Department of Public Health confirmed the first case of COVID-19 in Philadelphia. Eleven days later, COVID Watch , a patient outreach…

About this Blog Series As a former Marine, Ana Aluisy, MA, LMFT, has seen her fair share of conflict. In her work as a marriage and family therapist, she has…

More than 100,000 people in the United States have sickle cell disease —a group of inherited red blood cell disorders that affect blood flow and the body’s use of oxygen…

PCORI’s third funding cycle of the year opens September 7, seeking projects that answer questions about the most effective treatments for a variety of topics, study the best ways to…

The COVID-19 pandemic triggered many uncertainties and concerns for pregnant people, who were faced with navigating frequent prenatal and postpartum healthcare visits under risk of COVID-19 exposure. The pandemic has…

Our efforts to engage patients and stakeholders across the healthcare community, and focus on outcomes of interest to patients and those who care for them, are how we conduct Research…

Health disparities are pervasive and persistent in the United States . Despite growing recognition that disparities exist, health inequities based on gender, race, socioeconomic status, and other demographic factors remain…

Conducting clinical research studies often takes years, from recruiting participants to analyzing data. It can often take many more years for new evidence from research to inform health care and…

PCORI is always looking for ways to respond to stakeholder feedback and enhance our processes to achieve our mission more effectively. I am pleased to report on some recent and…

One of the goals PCORI set in its strategic plan is to influence research to become more patient-centered. Engaging patients and healthcare stakeholders in the research process is central to…

This month PCORI joins researchers, people with lived experience, health experts, medical professionals, and millions of other stakeholders to mark National Suicide Prevention Month. Suicide is the tenth leading cause…

Every time a parent leaves our neonatal intensive care unit (NICU) to take their child home, we are asking them to do superhuman things. At Children’s National Hospital, the tasks…

An array of PCORI Funding Announcements (PFAs) open for Letters of Intent (LOI) on Tuesday, May 4, including three targeted announcements seeking projects on areas of acute interest. Two of…

Telehealth—the use of digital information and communication technologies, such as computers and mobile devices, to access health care services remotely and manage health care—has grown in promise as technology has…

We opened our online system for an array of PCORI Funding Announcements (PFAs) September 1, including Suicide Prevention: Brief Interventions for Youth . This PFA was developed in response to…

Mental health is a topic that some people feel uncomfortable discussing. But failing to spread mental health awareness can have serious consequences. For example, people with serious mental illness (SMI)—conditions…

As Americans’ use of cell phones and the internet have increased rapidly, clinicians and researchers have realized that telehealth may help people better manage their health. Telehealth, which involves clinicians…

One in six US adults lives with a mental illness such as depression, bipolar disorder, and anxiety disorders, according to the National Institute of Mental Health. Compared with non-Hispanic whites…