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The eighth PCORI Annual Meeting last month highlighted so much of what makes our community special: a broad, diverse range of engaged stakeholders; inspirational expert speakers; compelling results from patient-centered…

PCORI’s portfolio of funded research projects is home to more than 700 patient-centered outcomes research/comparative clinical effectiveness research (PCOR/CER) studies aiming to generate important evidence about health conditions and treatment…

Conducting clinical research studies often takes years, from recruiting participants to analyzing data. It can often take many more years for new evidence from research to inform health care and…

People with cardiovascular disease (CVD) taking aspirin to lower their chances of suffering a heart attack or stroke experienced similar health benefits, including reduced death and hospitalization for heart attack and stroke, whether they took a high or low dose of aspirin, according to a study presented today at ACC.21, the American College of Cardiology’s 70th Annual Scientific Session and published in the New England Journal of Medicine.

As a major funder of comparative clinical effectiveness research—with more than $2.8 billion awarded to support more than 1,700 research and related projects—PCORI holds a strong commitment to increase the…

ABC News’ flagship morning program Good Morning America recently featured an online story on care for people with Down syndrome that highlighted a PCORI-funded project. The story about 28-year-old Cristina…

Early results from a PCORI-funded study show that seven in 10 adults with uncomplicated appendicitis were able to safely delay surgery for at least three months by taking a course…

At PCORI, our mission is to fund research that can help patients and those who care for them make better-informed decisions about their health care. When people contribute to this…

A new, large study involving more than 2 million anonymized patient records found roughly one in 10 people infected with COVID-19 developed new symptoms or health conditions associated with what’s…

Results of a study appearing in the April 1 issue of the CDC's Morbidity and Mortality Weekly Report will enable a better understanding about the comparative risks of heart complications…

Each year, more than 300,000 adults in the United States break a hip and nearly all will need surgery. The PCORI-funded REGAIN Trial , comparing how general anesthesia and spinal…

Pediatric patients receiving the tumor necrosis factor (TNF) inhibitor adalimumab, combined with a low dose of methotrexate, a second immunosuppressant, to treat Crohn’s disease did better than those treated with…

Proper diagnosis of hypertension can save a patient’s life. But blood pressure varies a lot over the day and one or two measurements in a clinic may not reflect a…

Kawasaki disease is a rare form of cardiovascular disease that mainly affects children. The condition causes widespread inflammation and can lead to focal swelling, or aneurysm formation, of the arteries…

Although new results from an ongoing PCORI-funded study into whether some patients with multiple sclerosis (MS) can safely stop taking certain kinds of medications as they age weren’t conclusive in…

A PCORI-funded research registry of more than 55,000 healthcare workers and their families has powered a study that provides important insights into the psyche of COVID-19 healthcare workers during the…

For older adults, guidelines recommend clinicians and patients work together to make decisions about colorectal cancer screening (CRC). However, these conversations must consider several factors and can be challenging. The…

Some patients who receive chemotherapy develop a serious health problem called febrile neutropenia (FN), which involves having a fever and a low number of a type of white blood cells…

Patients with advanced cancer who used telehealth to regularly report symptoms improved their overall well-being, compared with those who were seen less frequently via in-person clinical visits, according to results…

A system designed to monitor COVID-19 patients at home using automated text messages saved a life about twice a week during the early days of the pandemic, and overall, patients…

Many people with chronic migraines use medication more often than recommended. This overuse can have the undesired effect of more migraines and headaches and other serious side effects. The PCORI-funded…

Underscoring the health inequities that have characterized the COVID-19 pandemic, an analysis of health data accessed via a PCORI-funded network suggests that monoclonal antibodies, medications highly effective at lessening the…

Adults with anxiety disorders can experience comparable relief from either meditation or a commonly prescribed medication, according to findings from a PCORI-funded study published in JAMA Psychiatry . For the…

An estimated one in three people with clinical depression do not respond to antidepressants, limiting their treatment option to electroconvulsive therapy (ECT), which has been linked to physical and mental…

About 37 million Americans live with chronic kidney disease (CKD) and may not know about their options for treatment or the benefits and harms of each choice. A PCORI-funded research…