- Our Programs
- Our Vision & Mission
- PCORI's New Strategic Plan
- Financials and Reports
- Evaluating Our Work
- Executive Team
- Office of the Executive Director
- Program Support and Information Management
- Staff Conflict of Interest Disclosures
- PCORI's Advisory Panels
- Procurement Opportunities
Past Opportunities to Provide Input
- Proposed National Priorities for Health (2021)
- Proposed Principles for the Consideration of the Full Range of Outcomes Data in PCORI-Funded Research (2020)
- Proposed New PCORI Methodology Standards (2018)
- Data Access and Data Sharing Policy: Public Comment (2017)
- Proposed New PCORI Methodology Standards (2017)
Comment on the Proposed New and Revised PCORI Methodology Standards (2016)
- 1. Standards for Formulating Research Questions
- 10: Standards for Studies of Diagnostic Tests
- 12. Standards on Research Designs Using Clusters
- 13: General Comments on the Proposed Revisions to the PCORI Methodology Standards
- 2: Standards Associated with Patient-Centeredness
- 3: Standards for Data Integrity and Rigorous Analysis
- 4: Standards for Preventing and Handling Missing Data
- 5: Standards for Heterogeneity of Treatment Effects
- 6: Standards for Data Registries
- 7: Standards for Data Networks as Research-Facilitating Structures
- 8. Standards for Causal Inference Methods
- 9. Standards for Adaptive Trial Designs
- Peer-Review Process Comments (2014)
- Draft Methodology Report Public Comment Period (2012)
- Past Opportunities to Provide Input
- PCORI News Hub
Why PCORI Was Created
Patients, their families, and clinicians face a wide range of complex and often-confusing choices when it comes to health and healthcare concerns. They need trustworthy information to decide which treatment or other care option is best for them.
Unfortunately, traditional health research, for all the remarkable advances it produces, hasn’t been able to answer many of the questions patients and their clinicians face daily. The Patient-Centered Outcomes Research Institute (PCORI), an independent nonprofit, nongovernmental organization in Washington, DC, was authorized by Congress in 2010 to close that gap.
Our mandate is to improve the quality and relevance of evidence available to help patients, caregivers, clinicians, employers, insurers, and policy makers make better-informed health decisions. To do this, we work with those healthcare stakeholders to identify critical research questions and answer them through comparative clinical effectiveness research, or CER, focusing on outcomes important to patients. We also disseminate the results in ways that members of the healthcare community will find useful.
Since December 2012, we have funded hundreds of studies that compare healthcare options to learn which works best, given patients’ circumstances and preferences.
As the largest public research funder that focuses primarily on CER, we issue funding announcements several times each year that call for proposals for CER projects.
We include patients and other healthcare stakeholders throughout the research process, so the resulting evidence will address their most important questions and concerns. We also provide awards to encourage engagement of patients and other healthcare stakeholders in CER.
In addition, as directed by our authorizing law, we fund research to develop and improve CER methods. We know methods matter when it comes to producing valid and trustworthy information that will lead to better healthcare decisions and, ultimately, improved patient outcomes.
Our mandate and mission are broad and complex, but in our Strategic Plan, we outline three overarching goals.
- Substantially increase the quantity, quality, and timeliness of useful, trustworthy information available to support health decisions
- Speed the implementation and use of patient-centered outcomes research (PCOR) evidence
- Influence clinical and healthcare research funded by others to be more patient-centered
Find out more about how we evaluate our work on funding comparative clinical effectiveness research here.
Supporting these goals are five mutually reinforcing imperatives.
- Engagement: Engage patients, caregivers, and all other stakeholders in our entire research process, from topic generation to dissemination and implementation of results
- Methods: Develop and promote rigorous patient-centered outcomes research methods, standards, and best practices
- Research: Fund a comprehensive agenda of high-quality patient-centered outcomes research and evaluate its impact
- Dissemination and Implementation: Disseminate patient-centered outcomes research to all stakeholders and support its uptake and implementation
- Infrastructure: Promote and facilitate the development of a sustainable infrastructure for conducting patient-centered outcomes research
Underlying everything we do is a set of core values.
- Patient-Centeredness: Patients are our true north: we rely on patient perspectives and values to guide and improve our work.
- Usefulness: We focus on funding research that provides actionable answers to questions that are important to patients and the healthcare community.
- Transparency: We work in the open and facilitate public access to build trust, encourage participation, and promote implementation.
- Inclusiveness: We study broad patient populations and seek to provide evidence that is tailored to patients’ demographic or clinical characteristics and their preferences.
- Evidence: We consistently rely on the best available science and we evaluate our work to improve its reliability and utility.
More About PCORI
PCORI's Mission to Help People Make Informed Healthcare Decisions
Our Executive Director outlines PCORI’s creation and mission to fund research that helps people make better-informed healthcare decisions based on their needs and preferences.
Asking the Right Questions in Research
A patient coinvestigator on a PCORI-funded study says patient engagement in research helps researchers ask the right questions.
More About PCORI's Research Priorities and Research Funding
Our National Priorities for Health serve as ambitious long-term goals to guide PCORI’s funding of patient-centered comparative clinical effectiveness research (CER) and other engagement, dissemination and implementation, and research infrastructure initiatives.
PCORI has awarded more than $3.3 billion for more than 1,800 research and related projects, including those that support the methods and capacity for conducting that research. We also provide support for patient and stakeholder involvement in the research process.