PCORI funds research that offers patients and caregivers the information they need to make important healthcare decisions. Our scientific research portfolio is divided between two programs—Clinical Effectiveness and Decision Science (CEDS) and Healthcare Delivery and Disparities Research (HDDR). These programs support our National Priorities for Health, mutually reinforcing goals that focus on impact and drive our research funding and other initiatives. Each program leads the development of PCORI Funding Announcements that may be either broad calls for applications or targeted to specific topics. These programs also participate in the selection of awards and oversee the projects as they progress.

In addition, the Evaluation and Analysis program provides evaluation expertise, while the Engagement program gives patients, caregivers, clinicians, and other healthcare stakeholders opportunities for meaningful involvement in all our activities.

Clinical Effectiveness and Decision Science

When deciding how to address a health problem, patients and those who care for them often need to choose between two or more options. To make the best decision, they must be able to access and use reliable information about the options’ potential benefits and harms. The Clinical Effectiveness and Decision Science (CEDS) program seeks to fill clinical information gaps by producing valid, trustworthy, and useful new evidence comparing the effectiveness of different clinical options.

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Dissemination and Implementation

Promoting the uptake of research findings is part of PCORI’s legal mandate to improve the quality and relevance of evidence available to help patients, caregivers, clinicians, and others make better-informed health decisions.

PCORI’s release of new evidence begins with posting short, understandable summaries of all research findings soon after a study’s results are final. Our efforts continue with programs and activities to promote awareness of findings from PCORI-funded research (dissemination) and to facilitate the uptake of research findings in practice settings (implementation).

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Bringing together all healthcare stakeholders—with patients at the center—to help set research priorities and evaluate applications is our formula for ensuring we fund and conduct the most relevant research. We believe that inclusion of patients and other stakeholders in the research process, from topic selection through dissemination and implementation of results, will lead to trustworthy and usable information likely to be taken up in practice.

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Evaluation and Analysis

In our effort to function as a learning organization and be effective in reaching our goals, we pursue a wide range of evaluation activities, which are housed in the Evaluation and Analysis (E&A) program. These are organized into a framework, which flows from our strategic and operational plans and incorporates our stakeholders’ perspectives and priorities.

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Healthcare Delivery and Disparities Research

The Healthcare Delivery and Disparities Research (HDDR) program focuses on comparing patient-centered approaches to improve the equitability, effectiveness, and efficiency of care.

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PCOR Infrastructure and Innovation

The PCOR Infrastructure and Innovation division is leading PCORI's efforts to develop a sustainable and effective infrastructure for conducting patient-centered outcomes research (PCOR) and influencing clinical and health care research funded by others to be more patient-centered through:

  • Developing, managing and promoting research, data and technology infrastructure for PCOR.
  • Expanding workforce capacity to lead or partner in PCOR.
  • Developing and promoting rigorous PCOR research and engagement methods, standards and best practices.

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Posted: September 10, 2014; Updated: September 22, 2022

What's Happening at PCORI?

The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.

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