On April 19 and 20, 2013, we convened the Advisory Panel on Assessment of Prevention, Diagnosis, and Treatment Options for training and initial discussions about research prioritization. The panel reviewed 20 research topics against PCORI’s research criteria and selected four topics for further consideration: 

• Bipolar disorder—Compare the effectiveness of medication regimens for adolescents and young adults with bipolar disorder (Topic 2).
• Ductal carcinoma in situ—Compare the effectiveness of management strategies for ductal carcinoma in situ among women who had this diagnosis made after undergoing screening mammography (Topic 7).
• Migraine headache—Compare the effectiveness of treatment strategies for adults with episodic and chronic migraine headaches (Topic 17).
• Osteoarthritis—Compare the effectiveness of alternative strategies for stabilizing symptoms in people with osteoarthritis (Topic 20).

The selection of topics was supported by a review of research prioritization briefs. Below is a full list of these briefs. (Download the full set of briefs)

Topic 1 “Attention Deficit Hyperactivity Disorder (ADHD)” Comparative effectiveness of treatment options for attention deficit hyperactivity disorder (ADHD) in children. 

Topic 2 “Bipolar Disorder" Comparative effectiveness of antipsychotics for adolescents and young adults with bipolar disorder.

Topic 3 “Hip Fracture” Comparative effectiveness of surgical options for hip fracture in the elderly.

Topic 4 “Carotid Artery Disease” Comparative effectiveness of medical and surgical treatment options of patients with asymptomatic carotid artery stenosis.

Topic 5 “Cerebral Adrenoleukodystrophy (ALD)” Comparative effectiveness of early versus late bone marrow transplant treatment for children affected by adrenoleukodystrophy (ALD). 

Topic 6 “Coronary Artery Disease” Comparative effectiveness of coronary artery bypass surgery (CABG) and percutaneous coronary intervention (PCI) for treatment of adults with coronary artery disease.

Topic 7 “Ductal Carcinoma” Comparative effectiveness of management strategies for ductal carcinoma in situ (DCIS) among women who have had screening mammography.

Topic 8 “Gestational Diabetes” Comparative effectiveness of medical, surgical, and lifestyle treatment options in the prevention and treatment of gestational diabetes.

Topic 9 “Eczema” Comparative effectiveness of treatment options for topical or systemic eczema in children and adults.

Topic 10 “Epilepsy” Comparative effectiveness of treatment options for epilepsy in adults.

Topic 11 “Generalized Anxiety Disorder (GAD)” Comparative effectiveness of treatment options for generalized anxiety disorder (GAD) in adults.

Topic 12 “Hearing Loss” Comparative effectiveness of treatments for hearing loss in children and adults.

Topic 13 “Chronic Kidney Disease” Comparative effectiveness of treatment and prevention options for patients with chronic kidney disease. 

Topic 14 “Treatments for Liver Cancer” Comparative effectiveness of medical and surgical treatment options in patients with primary or metastatic malignancies of the liver in adults.

Topic 15 “Macular Degeneration” Comparative effectiveness of treatment for patients with age-related macular degeneration (AMD).

Topic 16 “Melanoma” Comparative effectiveness of using surgical treatment options to prevent recurrence of melanoma.

Topic 17 “Migraine Headache” Comparative effectiveness of different treatment strategies for adults with frequent migraine headaches. 

Topic 18 “Multiple Sclerosis” Comparative effectiveness of treatment programs for recurring/remitting multiple sclerosis (MS).

Topic 19 “Obstructive Sleep Apnea” Comparative effectiveness of medical and surgical treatment options for obstructive sleep apnea in adults.

Topic 20 “Osteoarthritis” Comparative effectiveness of treatment strategies for stabilization of symptoms from osteoarthritis.