- The PCORI Strategic Plan
- Our Programs
- Our Vision & Mission
- Financial Statements and Reports
- The PCORI Strategic Plan
- Board of Governors
- Methodology Committee
- Authorizing Law
- Evaluating Our Work
- PCORI's Advisory Panels
- Procurement Opportunities
- Patient-Centered Economic Outcomes Landscape (2023-2024)
Past Opportunities to Provide Input
- Systematic Review of Audio Care for the Management of Mental Health and Chronic Conditions (2023) -- Draft Key Questions
- Proposed New Methodology Standards for Usual Care as a Comparator (2023)
- Stakeholder Views on Components of 'Patient-Centered Value' in Health and Health Care (2023)
- PCORI's Proposed Research Agenda (2021-2022)
- Proposed National Priorities for Health (2021)
- Proposed Principles for the Consideration of the Full Range of Outcomes Data in PCORI-Funded Research (2020)
- Proposed New PCORI Methodology Standards (2018)
- Data Access and Data Sharing Policy: Public Comment (2017)
- Proposed New PCORI Methodology Standards (2017)
Comment on the Proposed New and Revised PCORI Methodology Standards (2016)
- 1. Standards for Formulating Research Questions
- 10: Standards for Studies of Diagnostic Tests
- 12. Standards on Research Designs Using Clusters
- 13: General Comments on the Proposed Revisions to the PCORI Methodology Standards
- 2: Standards Associated with Patient-Centeredness
- 3: Standards for Data Integrity and Rigorous Analysis
- 4: Standards for Preventing and Handling Missing Data
- 5: Standards for Heterogeneity of Treatment Effects
- 6: Standards for Data Registries
- 7: Standards for Data Networks as Research-Facilitating Structures
- 8. Standards for Causal Inference Methods
- 9. Standards for Adaptive Trial Designs
- Peer-Review Process Comments (2014)
- Draft Methodology Report Public Comment Period (2012)
In this unprecedented and challenging time, PCORI is gearing up to do all we can to address the threat COVID-19 poses to the nation’s health with a multipronged effort to support research on approaches to prevent and minimize effects of the virus.
A key piece of that effort is trying to ensure that those on the front lines of caring for people with the infection are getting the attention and support they so badly need. So, our Board of Governors today approved up to $50 million to fund a healthcare workers registry and rapid-turnaround clinical trial of whether hydroxychloroquine (HCQ) can prevent healthcare workers at high risk of contracting COVID-19 from becoming infected and unintentionally spreading the virus to others.
A team from the Duke Clinical Research Institute (DCRI) will lead this initiative, known as the Healthcare Worker Exposure Response and Outcomes (HERO) program. To speed this effort, DCRI researchers will leverage PCORnet®, the National Patient-Centered Clinical Research Network, the PCORI-funded national resource that taps into rich sources of real-world data to facilitate health research and quick and efficient sharing of information.
Plans call for the registry recruitment process to start in early April, with the study, known as the HERO-HCQ trial and involving about 40 PCORnet-associated sites across the United States, expected to begin later in the month.
A Broad Funding Approach
This trial is the largest and most immediate element in the plan PCORI is devising in response to this health emergency, but it’s not the only one. We also are providing funding for new research and programs seeking to improve COVID-19 care while making supplemental funds available to existing studies and projects that can address this issue. Altogether, PCORI is investing up to $110 million in high-quality, patient-centered research targeting coronavirus.
In addition to the funding for the HERO initiative, the Board today committed up to $30 million to fund other new COVID-19 research studies, as well as engagement and dissemination and implementation projects. PCORI staff already are working to identify proposed topics relating to the COVID-19 response that may be well-suited for large studies and other projects. Other topics are likely to come from key healthcare stakeholders involved in the country’s response.
A total of up to $20 million will go toward funding award increases for research and other projects related to the response. It will also address appropriate changes caused by the COVID-19 emergency. For instance, some researchers may revise their plans by adding coronavirus aims to their studies or switching to virtual environments.
Our existing programs and resources also will play a role. The Board approved up to $10 million for an existing fund earmarked for small, rapid-response projects.
Our commitment extends beyond funding research studies and dissemination and engagement projects. For example, we are highlighting the demands the virus is placing on our hospitals and healthcare systems now and in the months ahead through a series of webinars entitled Confronting COVID-19: Finding Hospital Capacity and Improving Patient Flow.
Hospitals across the country face enormous challenges because of the public health emergency. The four-part webinar series, which began this week, features a roster of clinicians and operations management experts who will discuss proven techniques for managing capacity that can be adapted to circumstances surrounding the current pandemic.
The Rest of Our Work Continues
Rest assured, PCORI remains committed to the extraordinary range of comparative clinical effectiveness research we have funded since the early days of our organization. We will continue to support these important endeavors while adding our efforts to contribute to the global effort to fight COVID-19.
Our work focuses on people. We never lose sight of the community of healthcare workers, researchers, clinicians, patients, and caregivers we are privileged to serve every day. And we never lose sight of the mission we are privileged to live every day.
That mission is as relevant as ever: PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.
Health and well-being are integral to our research funding, engagement with stakeholders, and our day-to-day operations. We will continue to assess the COVID-19 situation as we explore other ways PCORI can serve our nation.
April 16, 2020, 5:39 PM
Comment by PCORI Blog,
Hi, Samantha, thanks for reading. Details are still being finalized on a funding announcement for new awardees. Look for a funding opportunity preannouncement on our website in the next few weeks, with our system likely opening for research applications in early May.
April 16, 2020, 3:39 PM
Comment by Samantha Levin,
Similar to what Ms. Yawn mentions above, I see that there are opportunities posted/upcoming/closed for supplemental funding, but I do not see any reference for the rapid response funding or the new COVID-19 related funding opportunities for new awardees ( together $40 million.) Is there a timeline for these FOAs to be released?
April 15, 2020, 8:07 PM
Comment by PCORI Blog,
Thanks for reading and for the feedback. We have shared it with PCORI leadership, who will take it under advisement.
April 15, 2020, 8:04 PM
Comment by PCORI Blog,
An addressing disparities arm is likely to be included in a funding announcement in early May. Stay tuned to our Funding Opportunities page for more information in the coming days. And thanks for reading.
April 10, 2020, 4:52 PM
Comment by Lakiea Bailey,
I completely agree. We are already seeing a rise in anxiety and depression, exacerbated by the sense of isolation created during the quarantine. We are looking into ways to address this, along with general access to care, and finding barriers at every turn. I am very concerned about the mental impact this will inevitably have on our communities.
April 6, 2020, 9:13 PM
Comment by Michael Rice,
I have serious concerns about the ethics and wisdom of using front line providers as a testbed for the antimalaria drugs. Over 30% are within 5-10 years of retiring but are on these frontlines. Studies indicate that one series of 50 patients documented cardiac manifestations including pericarditis and myocardial infarction in approximately one-third of patients. see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760572/ The willingness to put those who are at greatest risk and whom we need the most, is concerning.
April 6, 2020, 6:37 PM
Comment by Ruby Benjamin-Garner,
Data is emerging that show the majority of deaths from the coronavirus is among African Americans and other underserved groups. Will there be funding available for community-based dissemination of valid information in hard-to-reach populations?
April 6, 2020, 6:11 PM
Comment by PCORI Blog,
Thanks for reading. Please keep up with deadlines by checking the Funding Opportunities tab on the pcori.org homepage.
April 2, 2020, 3:17 PM
Comment by Barbara Yawn,
Important opportunities are mentioned. When will the application processes be available and what are projected timelines for submission?
April 2, 2020, 6:54 AM
Comment by Evelinn Borrayo,
Focusing on the mental health impact of the COVID-19 pandemic is of utmost importance, as patients, caregivers, and healthcare providers are being traumatized by the experience. Anxiety, depression, and suicide are on the rise as the threat and deaths increase.
What's Happening at PCORI?
The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.