The Patient-Centered Outcomes Research Institute (PCORI) welcomes suggestions for comparative clinical effectiveness research (CER) questions that will result in practical information to help patients and other stakeholders make informed decisions about their health care and health outcomes. PCORI invites you to submit a research question.

PCORI is interested in questions that compare the effectiveness of two or more strategies for prevention, treatment, screening, diagnosis, or management of a condition; compare alternative system-level approaches; or compare factors that may affect patients' adherence to treatments. In addition, we also are interested in questions that would help to address disparities in health care, improve the communication of research findings, or advance methods for patient-centered CER. 

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Suggesting a research question is the first step in a six-part process to identify specific research topics for funding. We will carefully consider each question and, along with patients and other stakeholders, determine which ones we will fund. To see what PCORI has already funded, please visit our portfolio of funding awards.

Example Question: People with chronic obstructive pulmonary disease (COPD) need information on the safest and most effective way to quit smoking. How does a traditional education program on how to quit compare to a guided maintenance therapy program with nicotine replacement? (Read more about this project.)

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Posted: August 7, 2012; Updated: June 14, 2019

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The Patient-Centered Outcomes Research Institute sends weekly emails about opportunities to apply for funding, newly funded research studies and engagement projects, results of our funded research, webinars, and other new information posted on our site.

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