PCORI hosted a multi-stakeholder workshop to discuss whether comparative clinical effectiveness research (CER) can help to answer questions surrounding prevention of opioid misuse in the management of pain. We asked representatives of a wide range of stakeholder groups, including patients, caregivers, clinicians, industry, payers, and researchers to participate in this discussion.

Prescription opioid misuse is a national public health concern that detrimentally affects patients, families and communities. Understanding opioid use may be an important part of a treatment strategy for Americans living in chronic pain, there is also growing evidence of the harms related to misuse.  Most initiatives that seek to stem the tide of the epidemic focus on high-risk chronic opioid users. PCORI is interested in identifying and refining a set of research questions that would compare effective strategies to ensure the safe and appropriate prescribing and use of opioids in the management of non-cancer pain, including studying the comparative effectiveness of various public/private initiatives, care delivery strategies, and approaches to patient/provider interaction.

This workshop engaged patients and other stakeholders in discussing and prioritizing comparative clinical effectiveness research questions, as well as identifying key patient-centered outcomes to be measured.

In-person attendance was by invitation only, but the public was welcome to listen in via teleconference and webinar.

PCORI Workshops Introduction (9:00 am - 9:30 am ET)

Main Meeting Teleconference/Webinar (9:45 am - 5:00 pm ET)

Meeting Materials

Teleconference Audio Recordings


Morning Session

Afternoon Session

Breakout One: Provider/Patient-Level Communication and Dissemination Strategies

Breakout Two: Comprehensive System-Level Opioid and Pain Management Strategies

Breakout Three: Payer Strategies

Breakout Four: Comprehensive System-Level Opioid and Pain Management Strategies