Letters of Intent (LOIs) for the following Cycle 3 2022 Research
PCORI Funding Announcements (PFAs) were due October 4 by 5:00 pm ET.

PCORI's Online System opened on September 7, 2022, for the submission of LOIs for the following Cycle 3 2022 PFAs.


Telehealth to Optimize Management of Multiple Chronic Conditions among Vulnerable Populations in Primary Care

This PFA will solicit applications that respond to the following question: What is the comparative clinical effectiveness of different approaches to incorporating access to and use of telehealth to optimize management of multiple chronic conditions in primary care, particularly among vulnerable populations?

View the PFA to learn more.


Healthy Aging: Optimizing Physical and Mental Functioning Across the Aging Continuum

This PFA will solicit applications for research studies that focus on different phases of the aging continuum and aim to achieve one or more of the following four goals: maintaining function and independence; facilitating chronic disease management; supporting individuals with significant functional impairment; or reducing caregiving burden and improving quality of life.

View the PFA to learn more.


Phased Large Awards for Comparative Effectiveness Research

This PFA will solicit applications that respond to the following question: What is the comparative effectiveness of health system strategies to improve hypertension control for populations experiencing disparities in hypertension control and associated health outcomes, e.g., Black, Hispanic, rural, and/or uninsured individuals?

View the PFA to learn more.


Broad Pragmatic Studies

This PFA covers four broad areas -- Addressing Disparities; Assessment of Prevention, Diagnosis, and Treatment Options; Communication and Dissemination Research; and Improving Healthcare Systems -- that encompass the patient-centered comparative clinical effectiveness research (CER) that PCORI has long supported. Under this standing PFA for Cycle 3, PCORI will identify Special Areas of Emphasis (SAEs) to support innovative, high-impact studies that fit clearly within our core mission of patient-engaged and patient-centered comparative clinical effectiveness research. The PFA will be updated as SAEs are identified, which will occur no later than four weeks prior to the opening of the cycle.

View the PFA to learn more


Improving Methods for Conducting Patient-Centered Outcomes Research

Through this PFA, PCORI aims to fund studies that address high-priority methodological gaps in patient-centered outcomes research (PCOR) and CER, as well as projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by PCOR/CER studies. The PFA includes four areas of programmatic priorities.

View the PFA to learn more