Ableism is rooted in the assumption that people living without a disability are the ideal. Improving our knowledge of the term, disability can reduce stereotypes and stigma and improve disability inclusion in comparative clinical effectiveness research. In this session, we drew on the insights from three PCORI awardees to discuss how these considerations helped inform research design and disability inclusion in clinical trials. One project featured a Truth and Reconciliation resource on building trust between researchers and people with disabilities. Another project described efforts to create and disseminate an accessible research ethics training program that can be adopted by teams in collaboration with people with intellectual disabilities. Finally, the Disability Equity Collaborative described their efforts to provide evidence-based knowledge and practical solutions to address complex problems in disability access in healthcare.