Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
Funding Opportunity Type
Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 30 results

Project Title
Project Status
Project Type

Mining the Patients’ Voice to Improve Patient-Centered Outcomes Research Using Machine Learning

Yale University
| Connecticut
Samah Fodeh, M.S., Ph.D.
Project Status:
Awarded; In progress
Project Type:
Research

Causal Mediation Methods for Cluster-Randomized Pragmatic and Implementation Trials

Yale University
| Connecticut
Fan Li, Ph.D.
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparative Effectiveness of Racemic Ketamine versus S-Ketamine for Depression

Yale University
| Connecticut
Samuel Wilkinson, M.D.
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Peer Support Enhanced Behavioral Crisis Response Teams in the Emergency Department

Yale University
| Connecticut
Ambrose Wong, M.D., M.Ed., MS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Improving Postpartum Care for Black Pregnant and Postpartum People

Medical University of South Carolina
| South Carolina
Constance Guille, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Toward Improved Design and Analysis of Stepped Wedge Trials: An Estimand-Aligned and Efficiency-Focused Framework

Yale University
| Connecticut
Fan Li, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

PRESSURE POINTS: A Multilevel Team, Pragmatic Trial to Address Blood Pressure Control and Social Determinants of Health (SDOH)

Yale University
| Connecticut
Erica Spatz, M.D., MHS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

A TriaL ComparIng the EffectiVEness and ToleraBility of MEdicaTions in Older Adults with STablE Angina and Multiple ChRonic Conditions: LIVE BETTER

Yale University
| Connecticut
Michael Nanna, MD, MHS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Screen People for Anxiety, Substance Use Disorders, and Intimate Partner Violence before and after Giving Birth -- The LTWP Study

Medical University of South Carolina
| South Carolina
Constance Guille, MD, MSCR
Project Status:
In progress; Recruiting
Project Type:
Research

Community-Based, Family-Centered, Trauma-Informed Approach to Timely Detection and Management of Early Postpartum Hypertension

Yale School of Public Health
| Connecticut
Rafael Perez-Escamilla, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Developing New Methods for Assessing Heterogeneity of Treatment Effect in Cluster Randomized Trials

Yale School of Public Health
| Connecticut
Fan Li, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research
Has Results

Improving Methods for Extracting Data from Clinicians' Notes in Electronic Health Records

Medical University of South Carolina
| South Carolina
Paul M. Heider, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Two Ways to Provide Pregnant Women with Prenatal Care and Treatment for Opioid Use Disorder

Yale University School of Medicine
| Connecticut
Ariadna Forray
Project Status:
In progress; Data collected
Project Type:
Research

Comparing Two School Behavioral Health Programs to Improve Students' Academic Performance and Mental Health

University of South Carolina
| South Carolina
Mark Weist, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research
Has Results

Comparing Two Ways to Help Sexual and Gender Minority Men Who Have Been Sexually Abused Reduce Depression and Increase Mental Health Treatment Engagement

Yale University
| Connecticut
Joan M. Cook, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Engaging Patients in Diabetes-Focused Research to Improve Access, Self-Management, and Service Delivery

Upstate Affiliate Organization d/b/a Greenville Health System Health Sciences Center
| South Carolina
Peggy Wagner, LP
Project Status:
Completed
Project Type:
Pipeline to Proposal, Tier A
Has Results

Comparing Essure® and Tubal Ligation to Prevent Pregnancy

Yale University
| Connecticut
Aileen M. Gariepy, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

Partnership for Physical Rehabilitation Post Stroke - Tier III

Medical University of South Carolina
| South Carolina
Michelle Woodbury, PhD, OTR/L
Project Status:
Completed
Project Type:
Pipeline to Proposal, Tier III

Tailoring Patient Options (TPO) for Medication Adherence Action Plans in Community Pharmacies - Tier III

University of Connecticut
| Connecticut
Nathaniel Rickles, PharmD, PhD
Project Status:
Completed
Project Type:
Pipeline to Proposal, Tier III

Developing Comparative Effectiveness Research in Dravet Syndrome - Tier II

Dravet Syndrome Foundation
| Connecticut
Mary Anne Meskis
Project Status:
Completed
Project Type:
Pipeline to Proposal, Tier II

Developing Comparative Effectiveness Research in Dravet Syndrome - Tier I

Dravet Syndrome Foundation
| Connecticut
Mary Anne Meskis
Project Status:
Completed
Project Type:
Pipeline to Proposal, Tier I
Has Results

Developing New Statistical Methods for Clinical Studies Where Patients Choose Their Treatments

Yale University
| Connecticut
Denise Esserman, MS, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

Partnership for Physical Rehabilitation Post-stroke - Tier II

Medical University of South Carolina
| South Carolina
Na Jin Seo, PhD, MSE
Project Status:
Completed
Project Type:
Pipeline to Proposal, Tier II
Has Results

Comparing Treatment for Ductal Carcinoma In Situ (DCIS) with or without Sentinel Lymph Node Biopsy

Yale University
| Connecticut
Shiyi Wang, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Patient-Centered Hepatitis C Virus Care for People Who Inject Drugs -- The HERO Study

Clemson University^
| South Carolina
Alain Litwin, MD, MPH, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

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