Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 30 results

Project Title
Project Status
Project Type
Has Results

Comparing the Effects of Acupressure on Cancer Treatment Side Effects in Children and Youth -- The ACT-CC Study

University of California San Francisco
| California
E. Anne Lown, DPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Treatments for Resistant Kawasaki Disease -- The KIDCARE Study

University of California San Diego
| California
Jane C. Burns, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Does Treating Genital Herpes during Pregnancy Improve Birth Outcomes?

Kaiser Foundation Research Institute
| California
De-Kun Li, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Three Treatments for Adults with Major Depression That Does Not Respond to First-Line Treatment -- The ASCERTAIN TRD Study

Massachusetts General Hospital
| Massachusetts
George Papakostas, MD
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Has Results

Comparing Treatment Approaches for Older Adults with Treatment-Resistant Depression -- The OPTIMUM Study

Washington University School of Medicine
| Missouri
Eric J. Lenze, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing ECT and Ketamine in Adults with Treatment-Resistant Depression – The ELEKT-D Study

Cleveland Clinic Foundation
| Ohio
Amit Anand, MD^
Project Status:
In PCORI Peer-Review Process
Project Type:
Research

Comparing Two Oral Medicines to Improve Patient Experiences with Relapsing-Remitting Multiple Sclerosis -- PRAG-MS

Fondazione IRCCS Istituto Neurologico "Carlo Besta" (Italy)
| N/A
Renato Mantegazza, MD^
Project Status:
Terminated
Project Type:
Research
Has Results

Comparing the Safety and Effectiveness of Different Medicines to Treat Multiple Sclerosis -- The COMBAT-MS Study

Karolinska Institute (Sweden)
| N/A
Fredrik Piehl, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Medicines to Help Patients with Multiple Sclerosis Feel Less Fatigued -- The TRIUMPHANT-MS Study

Johns Hopkins University^
| Maryland
Bardia Nourbakhsh, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Medications Added to a Serotonin Reuptake Inhibitor to Treat Patients with PTSD

University of California San Francisco
| California
Beth Cohen, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Medicines for Long-Term Treatment of Bipolar Disorder

University of New Mexico Health Sciences Center
| New Mexico
Christophe G. Lambert, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Antibiotics and Surgery to Treat Appendicitis in Children

The Research Institute at Nationwide Children's Hospital
| Ohio
Peter C. Minneci, MD, MHSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Looking at the Effect of Treatment Duration for Newborn Infants Who Have Seizures

University of Michigan
| Michigan
Renée A. Shellhaas, MD, MS & Hannah C. Glass, MDCM, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Broad- and Narrow-Spectrum Antibiotics for Children with Ear, Sinus, and Throat Infections

The Children's Hospital of Philadelphia
| Pennsylvania
Jeffrey Gerber, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Help People with COPD Stop Smoking

University of Kansas Medical Center
| Kansas
Edward Ellerbeck, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Treatment and Patient Characteristics Affecting the Health Status of Patients with Peripheral Arterial Disease -- The PORTRAIT Study

Saint Luke's Hospital
| Missouri
Kim G. E. Smolderen, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Evaluating Whether Oxygen Treatment Helps People with Pulmonary Fibrosis Breathe Easier

National Jewish Health
| Colorado
Jeffrey Swigris, DO, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Anti-TNF Drugs versus Long-Term Steroid Use for Patients with Inflammatory Bowel Diseases

University of Pennsylvania
| Pennsylvania
James Lewis, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Different Medicines for People Who Have Had a Stroke -- The PROSPER Study

Duke University
| North Carolina
Adrian F. Hernandez, MD, MHS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Including Patient Traits in Benchmarks for Diabetes Care

Harvard University School of Public Health
| Massachusetts
Marcia Anne Testa, BA, MPH, MPHIL, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Effects of Maternal Depression and Its Treatment on Infant Health in Pregnant Women, with or without Other Mental Illness

Kaiser Foundation Research Institute
| California
De-Kun Li, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Does Plasma Exchange Help Improve Physical Function in Children with Transverse Myelitis? -- The CAPTURE Study

University of Texas Southwestern Medical Center
| Texas
Benjamin M. Greenberg, MD, MHS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Hematopoietic Cell Transplant versus Other Treatments for Adults with Acute Myeloid Leukemia

Fred Hutchinson Cancer Research Center
| Washington
Mohamed Lotfy Sorror, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Four Medicines to Treat Pain from Cryptogenic Sensory Polyneuropathy (CSPN) -- The PAIN-CONTRoLS Study

University of Kansas Medical Center
| Kansas
Richard J. Barohn, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Can Personalized Encouragement Help People with Sickle Cell Disease Take Hydroxyurea Therapy Regularly?

Emory University^
| Georgia
Lakshmanan Krishnamurti, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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