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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Displaying 1 - 25 of 32 results

Project Title
Project Status
Project Type

Efficacy of Pharmacologic Management of ADHD in Children and Youth with Autism Spectrum Disorder

The Research Institute at Nationwide Children's Hospital
| Ohio
Daniel Coury, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care

University of Florida
| Florida
Jesse Dallery, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research
Has Results

Comparing Ways to Promote Quitting Smoking for People Referred for Lung Cancer Screenings

University of Pennsylvania
| Pennsylvania
Scott Halpern, MD, PhD
Project Status:
In progress; Data collected
Project Type:
Research

Comparing Surgery and Medical Management for Treating Diverticulitis -- The COSMID Study

University of Washington
| Washington
David Flum, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research
Has Results

Comparing Inpatient Versus Outpatient Settings for Treating Teens after a Suicidal Event

Cincinnati Children's Hospital Medical Center
| Ohio
Drew Barzman, MD
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Remote Cognitive Behavior Therapy for Major Depression in Primary Care

University of South Florida
| Florida
Robert Bossarte, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Treatment Options for Recurrent Bladder Cancer

University of Washington Office of Sponsored Programs, Department of Urology
| Washington
John Gore, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Using Two Versus Three Antibiotics to Treat MAC Lung Infections

Oregon Health & Science University
| Oregon
Kevin Winthrop, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Strategies for Health Clinics to Increase HPV Vaccinations in Youth

UCLA School of Public Health
| California
Roshan Bastani, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Help Patients Manage Long-Term Non-Cancer Pain

RTI International
| North Carolina
Lauren A. McCormack, PhD, MSPH
Project Status:
In progress; Enrollment complete
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Cognitive Behavioral Therapy with Peer-Led Support Groups for Patients with Chronic Pain Who Want to Reduce Opioid Use -- The EMPOWER Study

Stanford University School of Medicine
| California
Beth Darnall, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research
Has Results

Examining Whether Early Aggressive Therapy Can Prevent or Delay Disability in People with Multiple Sclerosis: the TREAT-MS Study

Johns Hopkins University
| Maryland
Ellen M. Mowry, MD, MCR
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing the Effectiveness of Three Treatments for Reducing Fatigue among Patients with Multiple Sclerosis -- The COMBO-MS Trial

University of Michigan
| Michigan
Tiffany J. Braley, MD, MS
Project Status:
PCORI Peer-Review Process Complete
Project Type:
Research

Comparing Two Approaches to Treat Relapsing-Remitting Multiple Sclerosis -- the DELIVER-MS Study

Cleveland Clinic Foundation
| Ohio
Daniel Ontaneda, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two School-Based Programs to Prevent Dental Cavities in Communities with Fewer Resources and Hispanic Communities

New York University College of Dentistry
| New York
Richard Niederman, DMD
Project Status:
In progress; Data collected
Project Type:
Research

Comparing Two Antiseptic Skin Solutions to Prevent Infection in Patients Having Surgery to Treat Fractures -- The PREPARE Study

University of Maryland Baltimore
| Maryland
Gerard Slobogean, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Programs to Treat Opioid Use Disorder in Primary Care and Substance Use Clinics

Public Health Management Corporation^
| Pennsylvania
David R. Gastfriend, MD
Project Status:
Terminated
Project Type:
Research

Comparing Medicines that Prevent Blood Clots for Emergency Room Patients with Serious Fractures -- The PREVENT CLOT Study

University of Maryland Baltimore
| Maryland
Robert O'Toole, MD, TRD
Project Status:
In PCORI Peer-Review Process
Project Type:
Research

Comparing Ways to Help Veterans Manage Pain and Reduce Use of Prescription Opioid Medicines -- The VOICE Study

University of Minnesota Twin Cities
| Minnesota
Erin Krebs, MD, MPH
Project Status:
In PCORI Peer-Review Process
Project Type:
Research

Comparing Two Oral Medicines to Improve Patient Experiences with Relapsing-Remitting Multiple Sclerosis -- PRAG-MS

Fondazione IRCCS Istituto Neurologico "Carlo Besta" (Italy)
Renato Mantegazza, MD^
Project Status:
Terminated
Project Type:
Research
Has Results

Comparing Safety and Effectiveness of Medicines Patients Take for Many Years to Treat Multiple Sclerosis (MS) -- The COMBAT-MS Study

Karolinska Institute (Sweden)
Fredrik Piehl, MD, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research
Has Results

Comparing Medicines to Help Patients with Multiple Sclerosis Feel Less Fatigued -- The TRIUMPHANT-MS Study

Johns Hopkins University^
| Maryland
Bardia Nourbakhsh, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Manage Symptoms for Patients Who Have Chronic Migraine and Frequent Medication Use -- The MOTS Trial

Mayo Clinic Arizona
| Arizona
Todd J. Schwedt, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

Comparing Two Medicines to Prevent Chronic Obstructive Pulmonary Disease Episodes -- The RELIANCE Study

University of Illinois at Chicago
| Illinois
Jerry A. Krishnan, MD, PhD
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Asthma Treatments: A Study Focusing on African-American, Hispanic, and Latino Adults -- The PREPARE Study for PeRson EmPowered Asthma Relief

Brigham and Women's Hospital
| Massachusetts
Elliot Israel, MD
Project Status:
In PCORI Peer-Review Process
Project Type:
Research

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