Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 132 results

Project Title
Project Status
Project Type

Revascularization Choices Among Under-Represented Groups Evaluation (The RECHARGE Program)

Joan & Sanford I. Weill Medical College of Cornell University
| New York
Mario Gaudino, M.D., Ph.D.
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Annual Wellness Visits versus GRACE-augmented Annual Wellness Visits for Older Adults with High Needs

Massachusetts General Hospital
| Massachusetts
Christine Ritchie, M.D., MSPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparative Effectiveness of Generalist versus Specialist Palliative Care for Inpatients

University of Pennsylvania
| Pennsylvania
Scott Halpern, M.D., Ph.D.
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Trial of Sequential Medications AfteR TNF failure in Juvenile Idiopathic Arthritis (SMART-JIA)

Duke University
| North Carolina
Laura Schanberg, M.D.
Project Status:
Awarded; Contract pending
Project Type:
Research

The Missing Pieces Trial: A Multi-Site Pragmatic Comparative Effectiveness Trial of Interventions to Support Parents After Their Child's Unexpected or Traumatic Death

Ann & Robert H. Lurie Children's Hospital of Chicago
| Illinois
Kelly Michelson, M.D., MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Effectiveness of Interventions to Improve Resiliency and Burnout in Behavioral Health Residential Staff

Massachusetts General Hospital
| Massachusetts
Stephen Bartels, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Reducing Caregiver Burden and Improving Outcomes for Children with Tracheostomies Living at Home

Massachusetts General Hospital
| Massachusetts
Karen Sepucha, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis

Georgetown University Medical Center
| District of Columbia
Daniel Merenstein, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Two Pacing Treatments for Patients with Heart Failure

Baylor College of Medicine
| Texas
Mihail G. Chelu, MD, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Rapid Reversal of Acute Suicidal Depression across the Lifespan: A Pragmatic Comparative Effectiveness Trial of Electroconvulsive Therapy vs. Intravenous Ketamine Treatment

Brigham and Women's Hospital
| Massachusetts
Amit Anand, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD

Massachusetts General Hospital
| Massachusetts
Andrew Nierenberg, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

University of Pennsylvania
| Pennsylvania
Mucio Delgado, MD, MS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparative Effectiveness of In-Person and Telehealth Cardiac Rehabilitation

Regents of the University of California, San Francisco
| California
Alexis Beatty, MD, MAS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Help Patients Control High Blood Pressure

Brody School of Medicine at East Carolina University
| North Carolina
Doyle Cummings, PharmD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Screen People for Anxiety, Substance Use Disorders, and Intimate Partner Violence before and after Giving Birth -- The LTWP Study

Medical University of South Carolina
| South Carolina
Constance Guille, MD, MSCR
Project Status:
In progress; Recruiting
Project Type:
Research

Individualizing Treatment for Asthma in Primary Care

DARTNet Institute
| Kansas
Wilson Pace, MD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing Two Ways to Help Children with Complex Chronic Diseases Return Home after a Hospital Stay -- The GET2HOME Study

Cincinnati Children's Hospital Medical Center
| Ohio
Patrick Brady, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Monitor Symptoms from Dialysis -- The SMaRRT-HD Trial

The University of North Carolina at Chapel Hill
| North Carolina
Jennifer Flythe, MD, MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Two Ways to Follow Up after a Child Goes Home from the Hospital -- The FAAN-C Trial

University of Utah
| Utah
Eric Coon, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Screening Tests for Colon Cancer in Older Adults with a History of Colon Polyps -- The COOP Study

Dartmouth-Hitchcock Clinic
| New Hampshire
Audrey Calderwood, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide Palliative Care for Patients Who Are in the Hospital with Acute Myeloid Leukemia

Massachusetts General Hospital
| Massachusetts
Areej El-Jawahri, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide Anesthesia for Surgery -- The THRIVE Trial

Regents of the University of Michigan
| Michigan
Sachin Kheterpal, MD, MBA
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Control Blood Pressure after Stroke

Wake Forest University Health Sciences
| North Carolina
Cheryl Bushnell, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Medicines to Treat Type 2 Diabetes among Patients with or at High Risk for Heart Disease -- The PRECIDENTD Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Brendan Everett, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Two Prevention Programs for Teens at Risk for Suicide

Kaiser Foundation Research Institute
| Oregon
Gregory Clarke, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

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