Explore Our Portfolio
Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio |
Displaying 1 - 25 of 42 results
Project Title
Project Status
Project Type
Rapid Reversal of Acute Suicidal Depression across the Lifespan: A Pragmatic Comparative Effectiveness Trial of Electroconvulsive Therapy vs. Intravenous Ketamine Treatment
Brigham and Women's Hospital
| Massachusetts
Amit Anand, MD
Project Status:
In progress; Recruiting
Project Type:
Research
Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD
Massachusetts General Hospital
| Massachusetts
Andrew Nierenberg, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research
Implementing Matching of Patients to Mental Healthcare Therapists’ Strengths
University of Massachusetts Amherst
| Massachusetts
Michael Constantino, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Implementation Project (Limited Competition D&I PFA)
Comparing Behavior Therapy and Yoga for Treating Depression among Adults
Massachusetts General Hospital
| Massachusetts
Louisa Sylvia, PhD
Project Status:
In progress; Recruiting
Project Type:
Research
Comparing Two Ways to Provide Palliative Care for Patients Who Are in the Hospital with Acute Myeloid Leukemia
Massachusetts General Hospital
| Massachusetts
Areej El-Jawahri, MD
Project Status:
In progress; Recruiting
Project Type:
Research
Comparing Medicines to Treat Type 2 Diabetes among Patients with or at High Risk for Heart Disease -- The PRECIDENTD Study
Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Brendan Everett, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®
Comparing Second-Line Medicines to Treat Type 2 Diabetes -- The BESTMED Study
Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Alexander Turchin, MD, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research, Research Conducted Using PCORnet®
Has Results
Comparing the Effect of Four Diabetes Medicines on the Risk of Heart Disease among Patients with Type 2 Diabetes -- The CER-4-T2D Study
Brigham and Women's Hospital
| Massachusetts
Elisabetta Patorno, MD, DrPH
Project Status:
In progress; Recruitment not applicable
Project Type:
Research
Best Practices to Prevent COVID-19 Illness in Staff and People with Serious Mental Illness and Developmental Disabilities in Congregate Living Settings
Massachusetts General Hospital (The General Hospital Corp.)
| Massachusetts
Stephen Bartels, MD, MS
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Comparing Treatment for Opioid Use Disorder before and during the COVID-19 Pandemic
Boston VA Research Institute, Inc.
| Massachusetts
Nicholas Livingston, PhD and Risa Weisberg, PhD
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Comparing Two Therapies for Improving Social and Thinking Skills in Patients with Schizophrenia
Beth Israel Deaconess Medical Center, Inc
| Massachusetts
Matcheri S. Keshavan, MD, and Russell K. Schutt, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research
Expanding a Program to Help Clinics and Families Take Steps to Reduce Childhood Obesity
Massachusetts General Hospital
| Massachusetts
Elsie Taveras, MD, MPH
Project Status:
Completed
Project Type:
Implementation Project (Limited Competition D&I PFA)
Comparing Online and In-Person Cognitive Behavioral Therapy in Youth with Anxiety Disorders -- The Kids FACE FEARS Study
Boston Medical Center Corporation
| Massachusetts
Donna Pincus
Project Status:
In progress; Enrollment complete
Project Type:
Research
Has Results
Does a Decision Aid Help Older Adults with Chronic Kidney Disease Choose Treatment? -- The DART Study
Trustees of Tufts College
| Massachusetts
Keren Ladin, PhD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results
Comparing Ways to Treat Insomnia among Black Women
Boston University
| Massachusetts
Lynn Rosenberg, ScD, MS, and Eric Zhou, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results
Understanding the Effect of Gender-Affirming Hormone Therapy on Sexual Health and Depression for Transgender Adults
Brigham and Women's Hospital
| Massachusetts
Sari L. Reisner, ScD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Comparing the Effects of Three-Week versus Five-Week Courses of Radiation Therapy for Women with Breast Cancer Getting Mastectomy with Breast Reconstruction
Dana-Farber Cancer Institute
| Massachusetts
Rinaa Sujata Punglia, MD
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Using a Prediction Model to Identify Patients Who Can Benefit from Diabetes Prevention
Tufts Medical Center
| Massachusetts
David Kent, MD, MS
Project Status:
Completed
Project Type:
Implementation Project (Limited Competition D&I PFA)
Has Results
Comparing Two Ways to Treat Depression among Pregnant Women and New Mothers with Low Incomes
Boston Medical Center
| Massachusetts
Michael Silverstein, MD, MPH; Caroline J Kistin, MD, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results
Comparing Messaging Systems to Increase Use of Online Programs That Help Smokers Quit -- Smoker-to-Smoker (S2S)
University of Massachusetts Medical School
| Massachusetts
Rajani Sadasivam, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results
Comparing Three Treatments for Adults with Major Depression That Does Not Respond to First-Line Treatment -- The ASCERTAIN TRD Study
Massachusetts General Hospital
| Massachusetts
George Papakostas, MD
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Has Results
Comparing Standard and Short Online Mindfulness Therapy Programs for Improving Well-Being -- The Healthy Mind Healthy You Study
Massachusetts General Hospital
| Massachusetts
Andrew A. Nierenberg, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results
Comparing Preferences for Depression and Diabetes Treatment among Adults of Different Racial and Ethnic Groups Who Reported Discrimination in Health Care
Cambridge Health Alliance
| Massachusetts
Benjamin Cook, PhD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results
Comparing Three Ways to Increase Physical Activity in Patients with Depression and Cardiovascular Disease -- The Healthy Hearts Healthy Minds Study
Massachusetts General Hospital
| Massachusetts
Andrew A. Nierenberg, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Helping People with Serious Mental Illness Stop Smoking
Massachusetts General Hospital
| Massachusetts
Eden Evins, MD, MPH
Project Status:
In PCORI Peer-Review Process
Project Type:
Research