Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 31 results

Project Title
Project Status
Project Type
Has Results

Comparing One-Stage Versus Two-Stage Informed Consent for Clinical Trials

Sloan-Kettering Institute For Cancer Research
| New York
Andrew Vickers, DPhil
Project Status:
In progress; Recruitment not applicable
Project Type:
Research
Has Results

Developing Methods to Improve the Use of Information about Medicine Refills in Analyses of Electronic Health Record Data

Kaiser Permanente Division of Research
| California
Romain Neugebauer, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research
Has Results

Developing and Testing New Methods for Linking and Analyzing Multiple Data Sources with Limited Patient Identifiers

Brown University
| Rhode Island
Roee Gutman, PhD, MS, BSc
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Applying Results from Randomized Controlled Trials to Patients in Clinical Practice Using Hybrid Study Methods

The University of North Carolina at Chapel Hill
| North Carolina
Jennifer L. Lund, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Developing New Randomization Methods for Electronic Health Data Randomization to Conduct Comparative Effectiveness Research

Dartmouth College
| New Hampshire
Tor D. Tosteson, ScD, MS, BA
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

A New Statistical Method for Designing Stepped-Wedge Cluster Trials

University of Texas Southwestern Medical Center at Dallas
| Texas
Song Zhang, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Developing New Methods for Comparing Treatments in Case-Control Studies

Harvard T.H. Chan School of Public Health
| Massachusetts
Goodarz Danaei, MD, MS, DSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Testing Two Patient Surveys for Diagnosing Rare Genetic Conditions

Boston Children's Hospital
| Massachusetts
Ingrid A. Holm, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

Linking Randomized Clinical Trials and ClaiTRD Data for Enhancing Randomized and Non-Randomized Patient-Centered Outcomes Evidence Generation

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Mehdi Najafzadeh, PhD, MA, TRD
Project Status:
Awarded; Contract not executed
Project Type:
Research
Has Results

Comparing Three Treatments for Adults with Major Depression That Does Not Respond to First-Line Treatment -- The ASCERTAIN TRD Study

Massachusetts General Hospital
| Massachusetts
George Papakostas, MD
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Has Results

Comparing Treatment Approaches for Older Adults with Treatment-Resistant Depression -- The OPTIMUM Study

Washington University School of Medicine
| Missouri
Eric J. Lenze, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing ECT and Ketamine in Adults with Treatment-Resistant Depression – The ELEKT-D Study

Cleveland Clinic Foundation
| Ohio
Amit Anand, MD^
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Has Results

Comparing Preferences for Depression and Diabetes Treatment among Adults of Different Racial and Ethnic Groups Who Reported Discrimination in Health Care

Cambridge Health Alliance
| Massachusetts
Benjamin Cook, PhD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Developing a Process for Getting Patient and Caregiver Input on Clinical Practice Guidelines

RAND Corporation
| Massachusetts
Dmitry Khodyakov, PhD, MA
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Identify What's Important to Patients in Research

Thomas Jefferson University
| Pennsylvania
Kristin L. Rising, MD, MSHP
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Developing Methods to Account for Bias from Unmeasured Sources When Analyzing Time Until a Health Event

Dartmouth College
| New Hampshire
Alistair James O’Malley, BSc (Hons), MS, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

New Statistical Methods to Compare the Effectiveness of Adaptive Treatment Plans

Cincinnati Children's Hospital Medical Center
| Ohio
Bin Huang, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Statistical Methods to Preserve Patient Privacy When Sharing and Analyzing Data

Harvard Pilgrim Health Care ,Inc.
| Massachusetts
Darren Toh, ScD, BPHAR, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Methods for Comparing Treatments Using Different Ways of Grouping Patients

University of California, San Francisco^
| California
Mi-Ok Kim, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Creating and Testing Methods to Estimate Treatment Effect in Observational Studies with Three or More Treatments

Brown University
| Rhode Island
Roee Gutman, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Understanding and Improving Informed Consent for Clinical Trials during Health Emergencies

Emory University
| Georgia
Neal Dickert, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Statistical Models That Predict if Patients Will Take a New Medicine as Directed

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Joshua J. Gagne, TRD, PharmD, ScD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Methods for Improving Confounding Control in Comparative Effectiveness Research Using Electronic Healthcare Databases

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Sebastian Schneeweiss, MD, MS, ScD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Developing Software for Using Bayesian Regression to Evaluate Heterogeneity of Treatment Effects in Data from Randomized Controlled Trials

Johns Hopkins University
| Maryland
Ravi Varadhan, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Determining the Best Methods for Using Patient Registry Data in Clinical Research

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Daniel H. Solomon, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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