Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 27 results

Project Title
Project Status
Project Type

Comparing Two Types of Medicine for Pain after Surgery -- The CARES Trial

University of Michigan
| Michigan
Mark Bicket MD, PHD
Project Status:
In progress; Recruiting
Project Type:
Research
Has Results

Comparing the Safety and Effectiveness of Metformin with Other Medicines for Patients with Type 2 Diabetes and Chronic Kidney Disease

Joan and Sanford I. Weill Medical College of Cornell University
| New York
James Flory, MD, MSCE
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Ways to Help Primary Care Providers Prescribe Opioids Safely

University of Pittsburgh
| Pennsylvania
Kevin Kraemer, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Two Medicines for Adults with Myasthenia Gravis -- The PROMISE-MG Study

Duke University
| North Carolina
Donald B. Sanders, MD, and Pushpa Narayanaswami, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Medications Added to a Serotonin Reuptake Inhibitor to Treat Patients with PTSD

University of California San Francisco
| California
Beth Cohen, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Medicines for Long-Term Treatment of Bipolar Disorder

University of New Mexico Health Sciences Center
| New Mexico
Christophe G. Lambert, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Treatment with Long-Term Steroids or Long-Term Antibiotics to Prevent Lung Infections in Patients with Bronchiectasis

Oregon Health & Science University
| Oregon
Kevin Winthrop, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Stopping or Continuing Use of Disease Modifying Therapies in Older Adults with Multiple Sclerosis -- The DISCOMS Trial

University of Colorado Denver
| Colorado
John R. Corboy, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Effectiveness of a Home-Based Exercise Program on Walking Ability in Patients with Peripheral Artery Disease -- The HONOR Trial

Northwestern University
| Illinois
Mary McDermott, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Treatments for Improving Physical Function in Patients Who Had Knee Replacement Surgery

University of Pittsburgh at Pittsburgh
| Pennsylvania
Sara R. Piva, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Is Breast MRI Better at Finding Second Breast Cancers than Mammograms Alone for Breast Cancer Survivors?

Kaiser Permanente Washington Health Research Institute^
| Washington
Karen Joanne Wernli, PhD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

A Patient Decision Aid to Help Heavy Smokers Make Decisions about Lung Cancer Screening

University of Texas MD Anderson Cancer Center
| Texas
Robert J. Volk, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Improving Informed Consent for Palliative Chemotherapy

Dana-Farber Cancer Institute
| Massachusetts
Deborah Schrag, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Treatment and Patient Characteristics Affecting the Health Status of Patients with Peripheral Arterial Disease -- The PORTRAIT Study

Saint Luke's Hospital
| Missouri
Kim G. E. Smolderen, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Anti-TNF Drugs versus Long-Term Steroid Use for Patients with Inflammatory Bowel Diseases

University of Pennsylvania
| Pennsylvania
James Lewis, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Different Medicines for People Who Have Had a Stroke -- The PROSPER Study

Duke University
| North Carolina
Adrian F. Hernandez, MD, MHS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Five Activities to Improve Quality of Life for Patients with Mild Cognitive Impairment

University of Florida^
| Florida
Glenn E. Smith, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Physical Therapy, Internet-Based Exercise Training, and No Therapy for Knee Osteoarthritis

University of North Carolina Chapel Hill^
| North Carolina
Kelli D. Allen, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Hematopoietic Cell Transplant versus Other Treatments for Adults with Acute Myeloid Leukemia

Fred Hutchinson Cancer Research Center
| Washington
Mohamed Lotfy Sorror, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Treatments for Aortic Valve Disease

Duke University
| North Carolina
J. Matthew Brennan, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Does Daily Self-Monitoring of Blood Sugar Levels Improve Blood Sugar Control and Quality of Life for Patients with Type 2 Diabetes Who Do Not Use Insulin? -- The Monitor Trial

University of North Carolina Chapel Hill
| North Carolina
Katrina Donahue, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing the Effects of Surgery, Radiation Therapy, and Active Surveillance on Men with Localized Prostate Cancer -- The CEASAR Study

Vanderbilt University
| Tennessee
David Penson, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Predicting the Impact of Treatment Options on Survival and Breast Conservation in Patients with Ductal Carcinoma In Situ (DCIS)

Dana-Farber Cancer Institute
| Massachusetts
Rinaa Punglia, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Can Using Patient Reports of Low Back Pain Help to Better Direct Patients to Treatments?

Kaiser Foundation Health Plan of Washington^
| Washington
Dan Cherkin, PhD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Does an Online Decision Aid Help People with Advanced Chronic Kidney Disease Choose between Two Treatment Options?

Arbor Research Collaborative for Health
| Michigan
Lalita Subramanian, PhD, MPH^
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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