Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 67 results

Project Title
Project Status
Project Type

A TriaL ComparIng the EffectiVEness and ToleraBility of MEdicaTions in Older Adults with STablE Angina and Multiple ChRonic Conditions: LIVE BETTER

Yale University
| Connecticut
Michael Nanna, MD, MHS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Ways to Prevent Falls among Patients with Cirrhosis of the Liver

University of Michigan
| Michigan
Elliot Tapper, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide Palliative Care for Patients Who Are in the Hospital with Acute Myeloid Leukemia

Massachusetts General Hospital
| Massachusetts
Areej El-Jawahri, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Medicines to Treat Type 2 Diabetes among Patients with or at High Risk for Heart Disease -- The PRECIDENTD Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Brendan Everett, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Two Treatments for Children with Lennox-Gastaut Syndrome

Ann & Robert H. Lurie Children's Hospital of Chicago
| Illinois
Sandi Lam, MD, MBA
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Does Receiving Guidelines-Based Care Improve Health Outcomes for Adults with Congenital Heart Defects? -- The CHI-RON Study

Louisiana Public Health Institute
| Louisiana
Thomas Carton, PhD, MS
Project Status:
In progress; Enrollment complete
Project Type:
Research, Research Conducted Using PCORnet®

Supporting Families' Treatment Decisions with Evidence on Treatment of Urea Cycle Disorders

Children's National Health System
| District of Columbia
Nicholas Ah Mew, MD
Project Status:
In progress; Recruitment not applicable
Project Type:
Dissemination Project (Limited Competition D&I PFA)

Comparing Three Ways to Treat Children with Inactive Spondyloarthritis -- The BACK-OFF JSpA Study

Children's Hospital of Philadelphia
| Pennsylvania
Pamela Weiss, MD, AB
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Three Ways to Treat PTSD among Veterans

University of Pennsylvania Perelman School of Medicine
| Pennsylvania
Keith Bredemeier, PhD, BA
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Treat People with PTSD and Substance Use Disorder -- The COMPASS Study

Center for Veterans Research and Education
| Minnesota
Shannon M. Kehle-Forbes, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research

Comparing Primary Care Treatment Options for People with PTSD

University of Washington
| Washington
John Fortney, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research
Has Results

Comparing Two Ways to Help Patients with Sickle Cell Disease Manage Pain -- The CaRISMA Study

University of Pittsburgh
| Pennsylvania
Charles Jonassaint, PhD, MHS
Project Status:
In progress; Data collected
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Two School Behavioral Health Programs to Improve Students' Academic Performance and Mental Health

University of South Carolina
| South Carolina
Mark Weist, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research

What Is the Effect of Adding a Health Coach to Patient-Centered Medical Homes for Managing Multiple Chronic Conditions?

Clinical Directors Network
| New York
Jonathan Tobin, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research, Research Conducted Using PCORnet®

Using Two Versus Three Antibiotics to Treat MAC Lung Infections

Oregon Health & Science University
| Oregon
Kevin Winthrop, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Coordinate Care for Patients after Trauma

University of Washington
| Washington
Douglas Zatzick, MD
Project Status:
In progress; Data collected
Project Type:
Research

Comparing Strategies for Health Clinics to Increase HPV Vaccinations in Youth

UCLA School of Public Health
| California
Roshan Bastani, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Help Patients Manage Long-Term Non-Cancer Pain

RTI International
| North Carolina
Lauren A. McCormack, PhD, MSPH
Project Status:
In progress; Enrollment complete
Project Type:
Research, Research Conducted Using PCORnet®

Community Health Worker and Mobile Health Programs to Help Young Adults with Sickle Cell Disease Transition to Using Adult Healthcare Services -- The COMETS Study

The Childrens' Hospital of Philadelphia
| Pennsylvania
Tanisha Belton, DrPh, MPH
Project Status:
In progress; Enrollment complete
Project Type:
Research

Comparing Transitional Care for Teens and Young Adults with Sickle Cell Disease with and without Peer Mentoring

Atrium Health
| North Carolina
Payal Desai
Project Status:
In PCORI Peer-Review Process
Project Type:
Research

Comparing Two Ways to Offer Palliative Care to Improve Quality of Life for Patients with End-Stage Liver Disease

Thomas Jefferson University
| Pennsylvania
Victor J. Navarro, MD, BS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Ways to Encourage and Improve End-of-Life Care Planning

Duke University
| North Carolina
Kimberly Johnson, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research
Has Results

Identifying Barriers to Telehealth Home-Based Palliative Care for Patients with Serious Illness -- The HomePal Study

Kaiser Foundation Research Institute, a Division of Kaiser Foundation Hospitals
| California
Huong Q. Nguyen, PhD, RN
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Ways to Help Parents of Children with Sickle Cell Disease Decide on Treatment -- The ENGAGE HU Study

Cincinnati Children's Hospital Medical Center
| Ohio
Lori E. Crosby, PsyD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Two Medicines for Adults with Myasthenia Gravis -- The PROMISE-MG Study

Duke University
| North Carolina
Donald B. Sanders, MD, and Pushpa Narayanaswami, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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