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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 46 results

Project Title
Project Status
Project Type

The Missing Pieces Trial: A Multi-Site Pragmatic Comparative Effectiveness Trial of Interventions to Support Parents After Their Child's Unexpected or Traumatic Death

Ann & Robert H. Lurie Children's Hospital of Chicago
| Illinois
Kelly Michelson, MD, MPH
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparing Cognitive-Behavioral Therapy versus Mindfulness-Based Therapy for Autistic Adults

The University of North Carolina at Chapel Hill
| North Carolina
Brenna Maddox, PhD
Project Status:
Awarded; Contract pending
Project Type:
Research

A Comparison of Two School-Based Interventions to Manage Anxiety in Autistic Students

University of Colorado Denver
| Colorado
Judy Reaven, PhD
Project Status:
Awarded; Contract pending
Project Type:
Research

Hospital Elder Life Program (HELP) vs. Family-Augmented HELP (FAM-HELP) for Prevention of Delirium

Hebrew Rehabilitation Center
| Massachusetts
Sharon Inouye, MD, MPH
Project Status:
Awarded; Contract pending
Project Type:
Research

Testing Scalable, Broad-Reach School-Based Brief Interventions for Alcohol Use

Massachusetts General Hospital (The General Hospital Corp.)
| Massachusetts
Randi Schuster, PhD, MA
Project Status:
Awarded; Contract pending
Project Type:
Research

Adolescent-Only SBI versus Family-Based SBI in Primary Care for Adolescent Alcohol Use

Partnership to End Addiction
| New York
Aaron Hogue, PhD
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparing Scalable, Technology-Driven, Brief Intervention Packages for Youth Alcohol Use

Regents of the University of Michigan
| Michigan
Maureen Walton, PhD, MPH
Project Status:
Awarded; Contract pending
Project Type:
Research

Develop Novel Methods to Identify and Characterize Family Relationships from Electronic Health Data

University of Colorado Denver
| Colorado
Toan Ong, PhD, and Lisa Schilling, MD, MSPH
Project Status:
Awarded; Contract pending
Project Type:
Research

Effectiveness of Interventions to Improve Resiliency and Burnout in Behavioral Health Residential Staff

Massachusetts General Hospital
| Massachusetts
Stephen Bartels, MD, MS
Project Status:
Awarded; Contract pending
Project Type:
Research

Reducing Caregiver Burden and Improving Outcomes for Children with Tracheostomies Living at Home

Massachusetts General Hospital
| Massachusetts
Karen Sepucha, PhD
Project Status:
Awarded; Contract pending
Project Type:
Research

Can A/B Testing Be Adapted into an Ethical and Useful Approach to Patient-Centered Outcomes Research?

Memorial Sloan Kettering Cancer Center
| New York
James Flory, MD, MS
Project Status:
Awarded; Contract pending
Project Type:
Research

Data-Adaptive Readmissions Models for Heterogeneous and Longitudinal Data

Regents of the University of Minnesota
| Minnesota
Jared Huling, PhD
Project Status:
Awarded; Contract pending
Project Type:
Research

Diagnostic Tools for Quality Improvement of Machine Learning-Based Clinical Decision Support Systems

University of California, San Francisco
| California
Jean Feng, PhD, MS
Project Status:
Awarded; Contract pending
Project Type:
Research

Implementing Obesity Treatment in Primary Care Utilizing Evidence-Based Structures

University of Colorado Anschutz Medical Campus
| Colorado
Jodi Holtrop, PhD
Project Status:
Awarded; Contract pending
Project Type:
Implementation Project (Open Competition PFA: Implementation of Findings from PCORI’s Research Investments)

Employing a Stepped-Wedge Design to Implement an Evidence-Based Psychotherapy for PTSD in Six Large, Diverse Health Care Systems

Yale University
| Connecticut
Joan Cook, PhD
Project Status:
Awarded; Contract pending
Project Type:
Implementation Project (Open Competition PFA: Implementation of Findings from PCORI’s Research Investments)

Fast and Robust Weighting Methods for Targeted Comparative Effectiveness Research

President and Fellows of Harvard College
| Massachusetts
Jose Zubizarreta, PhD
Project Status:
Awarded; Contract pending
Project Type:
Research

Optimizing the Outcomes of Adults with Gram-Negative Bloodstream Infections

Johns Hopkins University School of Medicine
| Maryland
Pranita Tamma, MD, MHS
Project Status:
Awarded; Contract pending
Project Type:
Research

Promoting Shared Decision Making for Decisions about Treatment of Severe Aortic Stenosis

Massachusetts General Hospital
| Massachusetts
Karen Sepucha, PhD
Project Status:
Awarded; Contract pending
Project Type:
Research

Transportability of Machine Learning-Enabled Confounding Control Methods Across EHR Databases

Brigham and Women's Hospital
| Massachusetts
Richard Wyss, PhD, MS
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparative Effectiveness of an Individualized Model of Hemodialysis versus Conventional Hemodialysis

Wake Forest University Health Sciences
| North Carolina
Mariana Murea, MD
Project Status:
Awarded; Contract pending
Project Type:
Research

Treatment with Endovascular Intervention for Stroke Patients with Existing Disability

University of Cincinnati
| Ohio
Eva Mistry, MD, MS
Project Status:
Awarded; Contract pending
Project Type:
Research

Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis

Georgetown University Medical Center
| District of Columbia
Daniel Merenstein, MD
Project Status:
Awarded; Contract pending
Project Type:
Research

Rapid Reversal of Acute Suicidal Depression across the Lifespan: A Pragmatic Comparative Effectiveness Trial of Electroconvulsive Therapy vs. Intravenous Ketamine Treatment

Brigham and Womens Hospital, Boston
| Massachusetts
Amit Anand, MD
Project Status:
Awarded; Contract pending
Project Type:
Research

Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD

Massachusetts General Hospital
| Massachusetts
Andrew Nierenberg, MD
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparative Effectiveness of Brief Strength and Balance Exercises and Standard Home-Based Group Exercise for Primary Care Patients with Mobility Disability

Pennsylvania State University Hershey Medical Center
| Pennsylvania
Christopher Sciamanna, MD, MPH
Project Status:
Awarded; Contract pending
Project Type:
Research

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