Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 101 - 125 of 177 results

Project Title
Project Status
Project Type
Has Results

Comparing Standard and Short Online Mindfulness Therapy Programs for Improving Well-Being -- The Healthy Mind Healthy You Study

Massachusetts General Hospital
| Massachusetts
Andrew A. Nierenberg, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Medications Added to a Serotonin Reuptake Inhibitor to Treat Patients with PTSD

University of California San Francisco
| California
Beth Cohen, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Medicines for Long-Term Treatment of Bipolar Disorder

University of New Mexico Health Sciences Center
| New Mexico
Christophe G. Lambert, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Antibiotics and Surgery to Treat Appendicitis in Children

The Research Institute at Nationwide Children's Hospital
| Ohio
Peter C. Minneci, MD, MHSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Looking at the Effect of Treatment Duration for Newborn Infants Who Have Seizures

University of Michigan
| Michigan
Renée A. Shellhaas, MD, MS & Hannah C. Glass, MDCM, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Using Research Networks to Compare Medicines for Autoimmune and Inflammatory Diseases -- The Comparative Health Outcomes in Immune-mediated diseases CollaborativE (CHOICE) Study

University of Alabama at Birmingham
| Alabama
Jeffrey R. Curtis, MD, MPH, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Two Ways to Manage Symptoms for Patients Who Have Chronic Migraine and Frequent Medication Use -- The MOTS Trial

Mayo Clinic Arizona
| Arizona
Todd J. Schwedt, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

Comparing Two Medicines to Prevent Chronic Obstructive Pulmonary Disease Episodes -- The RELIANCE Study

University of Illinois at Chicago
| Illinois
Jerry A. Krishnan, MD, PhD
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Ways to Decrease Severe Asthma Attacks among Black and Latinx Adults with Moderate to Severe Asthma -- The PREPARE Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Elliot Israel, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Comparing Treatment Options for Women with Low-Risk Ductal Carcinoma In Situ (DCIS) -- The COMET Study

Alliance for Clinical Trials in Oncology Foundation
| Illinois
Shelley Hwang, MD, MPH
Project Status:
In progress; Enrollment complete
Project Type:
Research
Has Results

Comparing Treatment with Long-Term Steroids or Long-Term Antibiotics to Prevent Lung Infections in Patients with Bronchiectasis

Oregon Health & Science University
| Oregon
Kevin Winthrop, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Types of Blood Thinners to Prevent Blood Clots in Patients with Cancer -- The CANVAS Trial

Alliance for Clinical Trials in Oncology Foundation
| Illinois
Deborah Schrag, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Oral Medicines to Treat Hepatitis C Virus -- The PRIORITIZE Study

University of Florida
| Florida
David Robert Nelson, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Patient-Centered Hepatitis C Virus Care for People Who Inject Drugs -- The HERO Study

Clemson University^
| South Carolina
Alain Litwin, MD, MPH, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Two Treatment Approaches for Women with Ductal Carcinoma In Situ (DCIS) -- The PORTAL Study

Duke University
| North Carolina
E. Shelley Hwang, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Stopping or Continuing Use of Disease Modifying Therapies in Older Adults with Multiple Sclerosis -- The DISCOMS Trial

University of Colorado Denver
| Colorado
John R. Corboy, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Comparing Medicines to Prevent Blood Clots in Patients Who Have Hip or Knee Replacement Surgery -- The PEPPER Study

Dartmouth-Hitchcock Clinic^
| New Hampshire
Vincent Domenic Pellegrini, MD
Project Status:
In progress; Recruiting
Project Type:
Research
Has Results

Comparing Antibiotics versus Surgery for Treating Appendicitis -- The CODA Study

University of Washington
| Washington
David Reed Flum, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing the Safety and Effectiveness of Low-Dose versus High-Dose Aspirin to Prevent Problems from Heart Disease -- The ADAPTABLE Study -- A PCORnet® Study

Duke University
| North Carolina
William Schuyler Jones, MD*
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

New Statistical Methods to Compare the Effectiveness of Adaptive Treatment Plans

Cincinnati Children's Hospital Medical Center
| Ohio
Bin Huang, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Examining Whether a Self-Care Program Reduces Healthcare Use and Improves Health among Patients with Acute Heart Failure -- The GUIDED HF Study

Vanderbilt University Medical Center
| Tennessee
Sean P. Collins, MD, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Helping People with Opioid Use Disorders Avoid Relapses after Leaving Jail

University of Pennsylvania
| Pennsylvania
George Woody, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Changes in Health for Patients Who Complete Treatment for Chronic Hepatitis C Virus -- The PROP up TARGET Study

The University of North Carolina at Chapel Hill
| North Carolina
Donna Evon, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Three Ways to Start Treatment for Patients with Polyarticular Juvenile Idiopathic Arthritis -- The STOP-JIA Trial

Hackensack University Medical Center
| New Jersey
Yukiko Kimura, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Ways to Manage Weight and Overall Health in Overweight and Obese Youth with Bipolar Spectrum Disorders Who Take Antipsychotic Medicines -- The MOBILITY Study

University of Cincinnati
| Ohio
Melissa P. DelBello, MD, MS
Project Status:
PCORI Peer-Review Process Complete
Project Type:
Research

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