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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Displaying 1 - 25 of 30 results

Project Title
Project Status
Project Type

COOL PRIME: Cooling Mild HIE Parental Selection of Outcomes

UT Southwestern Medical Center
| Texas
Lina Chalak, MD
Project Status:
In progress; Recruiting
Project Type:
Research

LIVE-SMART: Liver Cirrhosis Interventions for Fall prevention - A Sequential, Multiple Assignment Randomized Trial

University of Michigan
| Michigan
Elliot Tapper, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Help Patients with Sickle Cell Disease Manage Pain -- The CaRISMA Study

University of Pittsburgh
| Pennsylvania
Charles Jonassaint, PhD, MHS
Project Status:
In progress; Data collected
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing a Multiple Sclerosis Fatigue Management Course Delivered via Teleconference, Internet, or in Person

Case Western Reserve University
| Ohio
Matthew A. Plow, PhD
Project Status:
In progress; Data collected
Project Type:
Research

Comparing Home and Facility-Based Exercise to Improve Mobility in People with Multiple Sclerosis -- STEP for MS

Shepherd Center
| Georgia
Deborah A. Backus, PhD, PT
Project Status:
In progress; Data collected
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Examining Whether Early Aggressive Therapy Can Prevent or Delay Disability in People with Multiple Sclerosis: the TREAT-MS Study

Johns Hopkins University
| Maryland
Ellen M. Mowry, MD, MCR
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing the Effectiveness of Three Treatments for Reducing Fatigue among Patients with Multiple Sclerosis -- The COMBO-MS Trial

University of Michigan
| Michigan
Tiffany J. Braley, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Comparing Two Approaches to Treat Relapsing-Remitting Multiple Sclerosis -- the DELIVER-MS Study

Cleveland Clinic Foundation
| Ohio
Daniel Ontaneda, MD
Project Status:
In progress; Recruiting
Project Type:
Research
Has Results

Comparing the Effect of Adding Acupuncture and Pain Counseling to Usual Care on Reducing Pain among Patients with Cancer -- The PRACXIS Study

University of California, San Francisco
| California
Maria Chao, DrPH, MPA
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Two Medicines for Adults with Myasthenia Gravis -- The PROMISE-MG Study

Duke University
| North Carolina
Donald B. Sanders, MD, and Pushpa Narayanaswami, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Understanding How Patients' Response to Treatment Varies Using Predicted Risk

Tufts Medical Center, Inc.
| Massachusetts
David Kent, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

Comparing Two Oral Medicines to Improve Patient Experiences with Relapsing-Remitting Multiple Sclerosis -- PRAG-MS

Fondazione IRCCS Istituto Neurologico "Carlo Besta" (Italy)
Renato Mantegazza, MD^
Project Status:
Terminated
Project Type:
Research

Comparing Clinic- and Home-Based Exercise Programs to Help Adults with Multiple Sclerosis -- The TEAMS Study

University of Alabama at Birmingham
| Alabama
James Rimmer, PhD, MA
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Has Results

Comparing the Safety and Effectiveness of Different Medicines to Treat Multiple Sclerosis -- The COMBAT-MS Study

Karolinska Institute (Sweden)
Fredrik Piehl, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Medicines to Help Patients with Multiple Sclerosis Feel Less Fatigued -- The TRIUMPHANT-MS Study

Johns Hopkins University^
| Maryland
Bardia Nourbakhsh, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Physical Therapy Schedules for Children with Cerebral Palsy -- The ACHIEVE Study

The Ohio State University
| Ohio
Jill C. Heathcock, MPT, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Looking at the Effect of Treatment Duration for Newborn Infants Who Have Seizures

University of Michigan
| Michigan
Renée A. Shellhaas, MD, MS & Hannah C. Glass, MDCM, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Surgery with and without Duraplasty for Youth with Chiari Malformation Type I and Syringomyelia

Washington University School of Medicine
| Missouri
David Limbrick, MD, MS, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Stopping or Continuing Use of Disease Modifying Therapies in Older Adults with Multiple Sclerosis -- The DISCOMS Trial

University of Colorado Denver
| Colorado
John R. Corboy, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Entry Sites for Cerebrospinal Fluid Shunts in Children with Hydrocephalus

Baylor College of Medicine
| Texas
William Whitehead, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Automated Tracking of Symptoms and Treatment Side Effects to Help Patients Starting New Medicines for Diabetes-Related Nerve Pain

Kaiser Foundation Research Institute
| California
Alyce Sophia Adams, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Reducing Burden on Hispanic Caregivers of Relatives with Dementia -- The Northern Manhattan Hispanic Caregiver Intervention Effectiveness Study (NHiCE)

Columbia University Health Sciences
| New York
Jose Alejandro Luchsinger, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Understanding the Development of Children with Cerebral Palsy and How Therapy May Affect Patient-Centered Outcomes

University of Washington
| Washington
Sarah Westcott McCoy, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Five Activities to Improve Quality of Life for Patients with Mild Cognitive Impairment

University of Florida^
| Florida
Glenn E. Smith, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Does Plasma Exchange Help Improve Physical Function in Children with Transverse Myelitis? -- The CAPTURE Study

University of Texas Southwestern Medical Center
| Texas
Benjamin M. Greenberg, MD, MHS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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