Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Displaying 1 - 25 of 121 results

Project Title
Project Status
Project Type

Revascularization Choices Among Under-Represented Groups Evaluation (The RECHARGE Program)

Joan & Sanford I. Weill Medical College of Cornell University
| New York
Mario Gaudino, M.D., Ph.D.
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Annual Wellness Visits versus GRACE-augmented Annual Wellness Visits for Older Adults with High Needs

Massachusetts General Hospital
| Massachusetts
Christine Ritchie, M.D., MSPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparative Effectiveness of Generalist versus Specialist Palliative Care for Inpatients

University of Pennsylvania
| Pennsylvania
Scott Halpern, M.D., Ph.D.
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Trial of Sequential Medications AfteR TNF failure in Juvenile Idiopathic Arthritis (SMART-JIA)

Duke University
| North Carolina
Laura Schanberg, M.D.
Project Status:
Awarded; Contract pending
Project Type:
Research

Treatment with Endovascular Intervention for Stroke Patients with Existing Disability

University of Cincinnati
| Ohio
Eva Mistry, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis

Georgetown University Medical Center
| District of Columbia
Daniel Merenstein, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Two Pacing Treatments for Patients with Heart Failure

Baylor College of Medicine
| Texas
Mihail G. Chelu, MD, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Rapid Reversal of Acute Suicidal Depression across the Lifespan: A Pragmatic Comparative Effectiveness Trial of Electroconvulsive Therapy vs. Intravenous Ketamine Treatment

Brigham and Women's Hospital
| Massachusetts
Amit Anand, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD

Massachusetts General Hospital
| Massachusetts
Andrew Nierenberg, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Future Planning and Well-Being for Individuals with Intellectual Disabilities and Family Caregivers

The Feinstein Institute For Medical Research
| New York
Sophia Jan, MD, MSHP
Project Status:
In progress; Recruiting
Project Type:
Research

Does Including a Health Coach in Well-Child Care Visits Improve Preventive Care for Families with Low Incomes?

Seattle Children's Research Institute
| Washington
Tumaini Coker, MD, MBA
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing Three Ways to Communicate with Children and Families who Speak Languages Other than English During a Hospital Stay -- The PFC I-PASS LISTEN Study

The Children's Hospital Corporation
| Massachusetts
Alisa Khan, MD, MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Individualizing Treatment for Asthma in Primary Care

DARTNet Institute
| Kansas
Wilson Pace, MD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing Two Ways for Parents of Youth with Intellectual and Developmental Disabilities to Build Their Advocacy Skills

The University of North Carolina at Chapel Hill
| North Carolina
Kathleen Thomas, MPH, PHD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide School-Based Mental Health Screening to Improve Access to Treatment for Black Students

University of Florida
| Florida
Joni Splett, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Does Treating Genital Herpes in Pregnancy Reduce Racial Disparities in Severe Maternal Morbidity? -- The PCORI SMM Study

Kaiser Foundation Research Institute, a Division of Kaiser Foundation Hospitals
| California
De-Kun Li, MD, MPH, PHD
Project Status:
In progress; Recruiting
Project Type:
Research

PEDSnet: Advancing Pediatric Patient-Centered Outcomes Research in PCORnet

The Children's Hospital of Philadelphia
| Pennsylvania
Christopher Forrest, MD, PhD
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

INSIGHT Clinical Research Network

Joan & Sanford I. Weill Medical College of Cornell University
| New York
Rainu Kaushal, MD, MPH
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

OneFlorida+ Partner Engagement Network

University of Florida
| Florida
Elizabeth Shenkman, PhD
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

Accelerating Data Value Across a National Community Health Center Network (ADVANCE) Clinical Research Network (CRN)

Oregon Community Health Information Network, Inc. (OCHIN)
| Oregon
Erika Cottrell, PhD, MPP
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

Greater Plains Collaborative Optimizing Infrastructure for Conducting Patient-Centered Outcomes Research: PCORnet, The National Patient-Centered Clinical Research Network: Phase 3

University of Missouri
| Missouri
Lemuel Waitman, PhD, MS, BS
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

The Stakeholders, Technology and Researchers (STAR) Clinical Research Network: Phase 3

Vanderbilt University Medical Center
| Tennessee
Russell Rothman, MD, MPP
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

PaTH to Health: PCORnet Clinical Research Network

University of Pittsburgh School of Medicine
| Pennsylvania
Kathleen McTigue, MD, MPH, MS
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

REACHnet 3.0: Optimizing Infrastructure for Conducting Patient-Centered Outcomes Research

Louisiana Public Health Institute
| Louisiana
Thomas Carton, PhD, MS, BS
Project Status:
Awarded; In progress
Project Type:
Research Infrastructure, PCORnet®: Clinical Research Network (Phase 3)

Comparing Two Screening Tests for Colon Cancer in Older Adults with a History of Colon Polyps -- The COOP Study

Dartmouth-Hitchcock Clinic
| New Hampshire
Audrey Calderwood, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

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