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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Displaying 1 - 25 of 37 results

Project Title
Project Status
Project Type

Does Treating Genital Herpes in Pregnancy Reduce Racial Disparities in Severe Maternal Morbidity? -- The PCORI SMM Study

Kaiser Foundation Research Institute, a Division of Kaiser Foundation Hospitals
| California
De-Kun Li, MD, MPH, PHD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Ways to Monitor and Treat High Blood Pressure in Children with Chronic Kidney Disease -- The PRESERVE Study

Children's Hospital of Philadelphia
| Pennsylvania
Christopher Forrest, MD, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Two Treatments for Children with Lennox-Gastaut Syndrome

Ann & Robert H. Lurie Children's Hospital of Chicago
| Illinois
Sandi Lam, MD, MBA
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Does Receiving Guidelines-Based Care Improve Health Outcomes for Adults with Congenital Heart Defects? -- The CHI-RON Study

Louisiana Public Health Institute
| Louisiana
Thomas Carton, PhD, MS
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing the Effects of Different Treatment Approaches for Neuroendocrine Tumors on Patient-Reported Outcomes -- The NET-PRO Study

University of Iowa
| Iowa
Michael O'Rorke, PhD, BSc
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Three Ways to Treat Children with Inactive Spondyloarthritis -- The BACK-OFF JSpA Study

Children's Hospital of Philadelphia
| Pennsylvania
Pamela Weiss, MD, AB
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Two Ways to Help Patients with Sickle Cell Disease Manage Pain -- The CaRISMA Study

University of Pittsburgh
| Pennsylvania
Charles Jonassaint, PhD, MHS
Project Status:
In progress; Data collected
Project Type:
Research, Research Conducted Using PCORnet®

Using Two Versus Three Antibiotics to Treat MAC Lung Infections

Oregon Health & Science University
| Oregon
Kevin Winthrop, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Community Health Worker and Mobile Health Programs to Help Young Adults with Sickle Cell Disease Transition to Using Adult Healthcare Services -- The COMETS Study

The Childrens' Hospital of Philadelphia
| Pennsylvania
David M. Rubin, MD, MS
Project Status:
In progress; Enrollment complete
Project Type:
Research

Comparing Transitional Care for Teens and Young Adults with Sickle Cell Disease with and without Peer Mentoring

Carolinas Medical Center
| North Carolina
Payal Desai
Project Status:
In progress; Data collected
Project Type:
Research

Comparing Two Ways to Help Parents of Children with Sickle Cell Disease Decide on Treatment with Their Doctors

Cincinnati Children's Hospital Medical Center
| Ohio
Lori E. Crosby, Psy.D
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Has Results

Comparing Two Medicines for Adults with Myasthenia Gravis -- The PROMISE-MG Study

Duke University
| North Carolina
Donald B. Sanders, MD, and Pushpa Narayanaswami, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Treatments for Resistant Kawasaki Disease -- The KIDCARE Study

University of California San Diego
| California
Jane C. Burns, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Two Physical Therapy Schedules for Children with Cerebral Palsy -- The ACHIEVE Study

The Ohio State University
| Ohio
Jill C. Heathcock, MPT, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Treatment with Long-Term Steroids or Long-Term Antibiotics to Prevent Lung Infections in Patients with Bronchiectasis

Oregon Health & Science University
| Oregon
Kevin Winthrop, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Treatment Options for Urea Cycle Disorders

Children's Research Institute
| District of Columbia
Nicholas Ah Mew, MD^
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Surgery with and without Duraplasty for Youth with Chiari Malformation Type I and Syringomyelia

Washington University School of Medicine
| Missouri
David Limbrick, MD, MS, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Chemotherapy Recovery at Home versus in the Hospital for Children with Acute Myeloid Leukemia

The Children's Hospital of Philadelphia
| Pennsylvania
Richard Aplenc, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Results of Three Treatments for Idiopathic Subglottic Stenosis

Vanderbilt University Medical Center
| Tennessee
Alexander Gelbard, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Three Ways to Start Treatment for Patients with Polyarticular Juvenile Idiopathic Arthritis -- The STOP-JIA Trial

Hackensack University Medical Center
| New Jersey
Yukiko Kimura, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Developmental Outcomes in Children with Duarte Galactosemia

Emory University
| Georgia
Judith L. Fridovich-Keil, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing the Safety and Effectiveness of Medicines to Treat Crohn’s Disease in Children and Adolescents -- The COMBINE Trial

The University of North Carolina at Chapel Hill
| North Carolina
Michael D. Kappelman, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Pain Management for Sickle Cell Disease Crises in Emergency Rooms and Infusion Centers

Johns Hopkins University
| Maryland
Sophie Lanzkron, MD, MHS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Restrictive Diets for Treating Eosinophilic Esophagitis in Children

Cincinnati Children's Hospital Medical Center
| Ohio
Marc Rothenberg, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Entry Sites for Cerebrospinal Fluid Shunts in Children with Hydrocephalus

Baylor College of Medicine
| Texas
William Whitehead, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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