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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Displaying 1 - 25 of 176 results

Project Title
Project Status
Project Type

Rapid Reversal of Acute Suicidal Depression across the Lifespan: A Pragmatic Comparative Effectiveness Trial of Electroconvulsive Therapy vs. Intravenous Ketamine Treatment

Brigham and Women's Hospital
| Massachusetts
Amit Anand, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

A TriaL ComparIng the EffectiVEness and ToleraBility of MEdicaTions in Older Adults with STablE Angina and Multiple ChRonic Conditions: LIVE BETTER

Yale University
| Connecticut
Michael Nanna, MD, MHS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparative Effectiveness of Brief Strength and Balance Exercises and Standard Home-Based Group Exercise for Primary Care Patients with Mobility Disability

Pennsylvania State University Hershey Medical Center
| Pennsylvania
Christopher Sciamanna, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Perioperative Physical Activity in Older Adults Undergoing Lung Cancer Surgery

City of Hope Beckman Research Institute
| California
Dan Raz, MD
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparative Effectiveness of In-Person and Telehealth Cardiac Rehabilitation

Regents of the University of California, San Francisco
| California
Alexis Beatty, MD, MAS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Healthcare Visit Recording and Open Notes to Improve the Chronic Illness Care Experience for Older Adults (The CHRONICLE Trial)

Trustees of Dartmouth College
| New Hampshire
Paul Barr, PhD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Effectiveness of a Multimodal Intervention for Transitions of Care after Lower Limb Fracture

Brigham and Women's Hospital
| Massachusetts
Patricia Dykes, PhD, RN, MA
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparing Two Ways to Monitor Symptoms from Dialysis -- The SMaRRT-HD Trial

The University of North Carolina at Chapel Hill
| North Carolina
Jennifer Flythe, MD, MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Beta-Agonist versus onabotulinumtoxinA Trial for Urgency Urinary Incontinence (Best Trial)

Women and Infants Hospital-Rhode Island
| Rhode Island
Vivian Sung, MD, MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Tailoring Incontinence Care: OnabotulinumtoxinA for Urgency Urinary Incontinence Among Older Women

Dartmouth-Hitchcock Clinic
| New Hampshire
Anne Cooper, MD, MA
Project Status:
In progress; Recruiting
Project Type:
Research

Comparative Efficacy of Advanced Practice Provider vs. Electronic Co-Management in a Diverse Population of Aging Women with Urinary Incontinence

University of California San Diego
| California
Jennifer Anger, MD, MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Two Online Programs for Treating Chronic Pain -- The PROGRESS Study

Stanford University
| California
Beth Darnall, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Analgesic Regimen Effectiveness and Safety After Surgery – The CARES Trial

University of Michigan
| Michigan
Mark Bicket MD, PHD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Screening Tests for Colon Cancer in Older Adults with a History of Colon Polyps -- The COOP Study

Dartmouth-Hitchcock Clinic
| New Hampshire
Audrey Calderwood, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide Palliative Care for Patients Who Are in the Hospital with Acute Myeloid Leukemia

Massachusetts General Hospital
| Massachusetts
Areej El-Jawahri, MD
Project Status:
In progress; Recruiting
Project Type:
Research

THRIVE: Trajectories of Recovery after Intravenous Propofol vs inhaled VolatilE anesthesia

Regents of the University of Michigan
| Michigan
Sachin Kheterpal, MD, MBA
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Control Blood Pressure after Stroke

Wake Forest University Health Sciences
| North Carolina
Cheryl Bushnell, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Medicines to Treat Type 2 Diabetes among Patients with or at High Risk for Heart Disease -- The PRECIDENTD Study

Brigham and Women's Hospital
| Massachusetts
Brendan Everett, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Two Ways to Provide Meals to Older Adults to Help Them Stay Healthy and Remain in Their Homes

Brown University School of Public Health
| Rhode Island
Kali Thomas, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing How Well Different Diabetes Medicines Reduce the Risk of Heart Disease

Kaiser Foundation Research Institute, a Division of Kaiser Foundation Hospitals
| California
Romain Neugebauer, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing Second-Line Medicines to Treat Type 2 Diabetes -- The BESTMED Study

Brigham and Women's Hospital
| Massachusetts
Alexander Turchin, MD, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Medicines to Treat Type 2 Diabetes among Patients Who Are at Risk for Heart Disease

Mayo Clinic
| Minnesota
Rozalina McCoy, MD, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing the Effect of Four Diabetes Medicines on the Risk of Heart Disease among Patients with Type 2 Diabetes -- The CER-4-T2D Study

Brigham and Women's Hospital
| Massachusetts
Elisabetta Patorno, MD, DrPH
Project Status:
In progress; Recruitment not applicable
Project Type:
Research
Has Results

Does Staff Training and Support for Using Infection Control Practices Prevent the Spread of COVID-19 in Nursing Homes?

Pennsylvania State University, Hershey Medical Center
| Pennsylvania
Jennifer Kraschnewski, MD, MPH
Project Status:
In PCORI Peer-Review Process
Project Type:
Research

Comparative Effectiveness Trial of Perioperative Telemonitoring for Functional Recovery and Symptoms

City of Hope
| California
Virginia Sun, PhD
Project Status:
In progress; Enrollment complete
Project Type:
Research

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