Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 188 results

Project Title
Project Status
Project Type
Has Results

Stroke and Blood Clot Risk in Transgender Women Taking Hormones

Emory University
| Georgia
Michael Goodman, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Supporting Shared Decision Making between Clinicians and Older Adults about Colorectal Cancer Screening -- The PRIMED Study

Massachusetts General Hospital
| Massachusetts
Karen Sepucha, PhD, and Leigh Simmons, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing the Safety and Effectiveness of Metformin with Other Medicines for Patients with Type 2 Diabetes and Chronic Kidney Disease

Joan and Sanford I. Weill Medical College of Cornell University
| New York
James Flory, MD, MSCE
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Universal versus Focused Screening for Depression among Teens in High School -- The SHIELD Trial

Penn State Health Milton S. Hershey Medical Center
| Pennsylvania
Deepa L. Sekhar, MD, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Ways for Patients, Doctors, and Clinics to Improve Blood Pressure Control -- A PCORnet® Study

University of California San Francisco
| California
Mark J. Pletcher, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Ways to Treat Insomnia among Black Women

Boston University
| Massachusetts
Lynn Rosenberg, ScD, MS, and Eric Zhou, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Evaluating Hormone Treatments for Women at Increased Risk for Preterm Birth -- The EPPPIC Study

University of York (United Kingdom)
| N/A
Lesley Stewart, PhD, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Ways to Help Primary Care Providers Prescribe Opioids Safely

University of Pittsburgh
| Pennsylvania
Kevin Kraemer, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing the Effect of Adding Acupuncture and Pain Counseling to Usual Care on Reducing Pain among Patients with Cancer -- The PRACXIS Study

University of California, San Francisco
| California
Maria Chao, DrPH, MPA
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Essure® and Tubal Ligation to Prevent Pregnancy

Yale University
| Connecticut
Aileen M. Gariepy, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Programs to Maintain Weight Loss among Black Women with Obesity

University of Florida
| Florida
Carolyn M. Tucker, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Understanding How Patients' Response to Treatment Varies Using Predicted Risk

Tufts Medical Center, Inc.
| Massachusetts
David Kent, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Treat Depression among Pregnant Women and New Mothers with Low Incomes

Boston Medical Center
| Massachusetts
Michael Silverstein, MD, MPH; Caroline J Kistin, MD, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Programs for Weight Loss among Marshallese Adults Living in the United States

University of Arkansas for Medical Sciences
| Arkansas
Pearl McElfish, PhD, MS, MBA
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Identifying and Treating Childhood Hearing Loss in Rural Alaska -- The Hearing Norton Sound Study

Norton Sound Health Corporation
| Alaska
Samantha Kleindienst Robler, AuD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Approaches to Help Patients and Doctors Talk about Chronic Pain Treatments -- Voices in Pain Care

Cedars-Sinai Medical Center
| California
Brennan Spiegel, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Understanding How to Use Single Patient Studies to Answer Patient-Identified Research Questions

Cincinnati Children’s Hospital Medical Center
| Ohio
Heather C. Kaplan, MD, MSCE; Lisa Opipari-Arrigan, PhD; Gregory M. Marcus, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Helping Women with Breast Cancer Choose between Surgical Treatment Options

Dartmouth College
| New Hampshire
Glyn Elwyn, MD, PhD, MSc^
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Ways to Identify Sleep Apnea in People with Traumatic Brain Injury during Inpatient Rehabilitation

Tampa VA Research and Education Foundation
| Florida
Risa Nakase-Richardson, PhD, FACRM, FNAN
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Does Treating Genital Herpes during Pregnancy Improve Birth Outcomes?

Kaiser Foundation Research Institute
| California
De-Kun Li, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Testing a Stepped-Care Program to Treat Emotional Distress among Patients with Lung or Head and Neck Cancer and Their Caregivers

University of Colorado Denver
| Colorado
Evelinn A. Borrayo, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing the Benefits and Harms of Different Long-Term Treatments for Blood Clots -- The DARE Warfarin Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Katsiaryna Bykov, PharmD, ScD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing the Effectiveness of Breast Cancer Screening and Diagnostic Tests among Women with Different Breast Densities -- The BCSC-ADVANCE Study

University of California, Davis
| California
Diana L. Miglioretti, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Provide Care for Adults Who Experience Intimate Partner Violence and Depression

University of Rochester
| New York
Catherine Cerulli, JD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Medications Added to a Serotonin Reuptake Inhibitor to Treat Patients with PTSD

University of California San Francisco
| California
Beth Cohen, MD, MAS
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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