Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 29 results

Project Title
Project Status
Project Type

Comorbidity of Chronic Pain and Early Cognitive Decline Among Older, Community-Based Black Adults: Comparative Effectiveness of Mindfulness-Based Cognitive Therapy with walking (MBCT) versus Active Living Every Day (ALED)

Massachusetts General Hospital
| Massachusetts
Olivia Okereke, A.B., M.D., M.S.
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Optimizing Childhood Obesity and Asthma Outcomes in Primary Care via Telehealth

Massachusetts General Hospital
| Massachusetts
Lauren Fiechtner, M.D., MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Annual Wellness Visits versus GRACE-augmented Annual Wellness Visits for Older Adults with High Needs

Massachusetts General Hospital
| Massachusetts
Christine Ritchie, M.D., MSPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Learning to Predict Disease Trajectories

Harvard Pilgrim Health Care ,Inc.
| Massachusetts
Mei-Sing Ong, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research, Research Conducted Using PCORnet®

Identification of Temporal Data Patterns Predictive of Adverse Outcomes in Patients with Diabetes

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Alexander Turchin, M.D., MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research, Research Conducted Using PCORnet®

An Online Platform to Promote Evidence-Based Care for Underserved Patients with Neurofibromatosis 1

Massachusetts General Hospital
| Massachusetts
Scott Plotkin, MD, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Hospital Elder Life Program (HELP) vs. Family-Augmented HELP (FAM-HELP) for Prevention of Delirium

Hebrew Rehabilitation Center
| Massachusetts
Sharon Inouye, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Testing Scalable, Broad-Reach School-Based Brief Interventions for Alcohol Use

Massachusetts General Hospital (The General Hospital Corp.)
| Massachusetts
Randi Schuster, PhD, MA
Project Status:
In progress; Recruiting
Project Type:
Research

Effectiveness of Interventions to Improve Resiliency and Burnout in Behavioral Health Residential Staff

Massachusetts General Hospital
| Massachusetts
Stephen Bartels, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Reducing Caregiver Burden and Improving Outcomes for Children with Tracheostomies Living at Home

Massachusetts General Hospital
| Massachusetts
Karen Sepucha, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Fast and Robust Weighting Methods for Targeted Comparative Effectiveness Research

President and Fellows of Harvard College
| Massachusetts
Jose Zubizarreta, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Promoting Shared Decision Making for Decisions about Treatment of Severe Aortic Stenosis

Massachusetts General Hospital
| Massachusetts
Karen Sepucha, PhD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Transportability of Machine Learning-Enabled Confounding Control Methods Across EHR Databases

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Richard Wyss, PhD, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Rapid Reversal of Acute Suicidal Depression across the Lifespan: A Pragmatic Comparative Effectiveness Trial of Electroconvulsive Therapy vs. Intravenous Ketamine Treatment

Brigham and Women's Hospital
| Massachusetts
Amit Anand, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD

Massachusetts General Hospital
| Massachusetts
Andrew Nierenberg, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Three Ways to Communicate with Children and Families who Speak Languages Other than English During a Hospital Stay -- The PFC I-PASS LISTEN Study

The Children's Hospital Corporation
| Massachusetts
Alisa Khan, MD, MPH
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Improving Methods for Benchmarking and Joint Analysis for Observational Studies

President and Fellows of Harvard College
| Massachusetts
Issa Dahabreh, MD, ScD, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing Behavior Therapy and Yoga for Treating Depression among Adults

Massachusetts General Hospital
| Massachusetts
Louisa Sylvia, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide Palliative Care for Patients Who Are in the Hospital with Acute Myeloid Leukemia

Massachusetts General Hospital
| Massachusetts
Areej El-Jawahri, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Medicines to Treat Type 2 Diabetes among Patients with or at High Risk for Heart Disease -- The PRECIDENTD Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Brendan Everett, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research, Research Conducted Using PCORnet®

Comparing Second-Line Medicines to Treat Type 2 Diabetes -- The BESTMED Study

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Alexander Turchin, MD, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing the Effect of Four Diabetes Medicines on the Risk of Heart Disease among Patients with Type 2 Diabetes -- The CER-4-T2D Study

Brigham and Women's Hospital
| Massachusetts
Elisabetta Patorno, MD, DrPH
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing Treatment for Opioid Use Disorder before and during the COVID-19 Pandemic

Boston VA Research Institute, Inc.
| Massachusetts
Nicholas Livingston, PhD and Risa Weisberg, PhD
Project Status:
In progress; Data collected
Project Type:
Research

Comparing Two Programs to Decrease HIV Risk among African-Born Black Women

Partners Healthcare Brigham and Women's Hospital
| Massachusetts
Bisola Ojikutu, MD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Systematic, Collaborative, PFO closure Evaluation (SCOPE) Study Conference: Research-Related Conference Support Award

Tufts Medical Center
| Massachusetts
David M. Kent, MD, MS
Project Status:
Awarded; In progress
Project Type:
Engagement in Research, Engagement Award Conference: Evidence Synthesis

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