Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 42 results

Project Title
Project Status
Project Type

Causal Mediation Methods for Cluster-Randomized Pragmatic and Implementation Trials

Yale University
| Connecticut
Fan Li, Ph.D.
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparing Analgesic Regimen Effectiveness and Safety for Kids After Surgery

University of Michigan
| Michigan
Mark Bicket, M.D., Ph.D.
Project Status:
Awarded; Contract pending
Project Type:
Research

Comparative Effectiveness of Racemic Ketamine versus S-Ketamine for Depression

Yale University
| Connecticut
Samuel Wilkinson, M.D.
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Peer Support Enhanced Behavioral Crisis Response Teams in the Emergency Department

Yale University
| Connecticut
Ambrose Wong, M.D., M.Ed., MS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Patient-Engaged Validation of the PEIR Survey Enhanced by Inclusion, Diversity, Equity, Acceptance and Safety (PEIR-IDEAS)

Henry Ford Health System
| Michigan
Sara Santarossa, Ph.D.
Project Status:
Awarded; Contract pending
Project Type:
Research

Toward Improved Design and Analysis of Stepped Wedge Trials: An Estimand-Aligned and Efficiency-Focused Framework

Yale University
| Connecticut
Fan Li, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

PRESSURE POINTS: A Multilevel Team, Pragmatic Trial to Address Blood Pressure Control and Social Determinants of Health (SDOH)

Yale University
| Connecticut
Erica Spatz, M.D., MHS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Scalable, Technology-Driven, Brief Intervention Packages for Youth Alcohol Use

Regents of the University of Michigan
| Michigan
Maureen Walton, PhD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

A TriaL ComparIng the EffectiVEness and ToleraBility of MEdicaTions in Older Adults with STablE Angina and Multiple ChRonic Conditions: LIVE BETTER

Yale University
| Connecticut
Michael Nanna, MD, MHS
Project Status:
In progress; Recruiting
Project Type:
Research

Does Omitting Stent Placement Improve Pain among Patients with Kidney Stones? -- The SOUL MUSIC Study

University of Michigan Medical School, Department
| Michigan
Khurshid Ghani, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Ways to Prevent Falls among Patients with Cirrhosis of the Liver

University of Michigan
| Michigan
Elliot Tapper, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Community-Based, Family-Centered, Trauma-Informed Approach to Timely Detection and Management of Early Postpartum Hypertension

Yale School of Public Health
| Connecticut
Rafael Perez-Escamilla, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Types of Medicine for Pain after Surgery -- The CARES Trial

University of Michigan
| Michigan
Mark Bicket MD, PHD
Project Status:
In progress; Recruiting
Project Type:
Research

Developing New Methods for Assessing Heterogeneity of Treatment Effect in Cluster Randomized Trials

Yale School of Public Health
| Connecticut
Fan Li, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Developing Methods to Combine and Analyze Data from PRPP-SMART Studies

University of Michigan
| Michigan
Kelley Kidwell, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Comparing Two Ways to Provide Anesthesia for Surgery -- The THRIVE Trial

Regents of the University of Michigan
| Michigan
Sachin Kheterpal, MD, MBA
Project Status:
In progress; Recruiting
Project Type:
Research

Advancement of PCORnet Infrastructure: Data Linkage Project with Aetna Affiliate Healthagen, LLC

Healthagen, LLC
| Connecticut
Cheryl Walraven, PhD
Project Status:
Completed
Project Type:
Research Infrastructure

Comparing Two Ways to Provide Pregnant Women with Prenatal Care and Treatment for Opioid Use Disorder

Yale University School of Medicine
| Connecticut
Ariadna Forray
Project Status:
In progress; Data collected
Project Type:
Research
Has Results

Understanding the Culture of Learning Health Networks

University of Michigan
| Michigan
Alexandra Vinson, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Help Sexual and Gender Minority Men Who Have Been Sexually Abused Reduce Depression and Increase Mental Health Treatment Engagement

Yale University
| Connecticut
Joan M. Cook, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing the Effectiveness of Three Treatments for Reducing Fatigue among Patients with Multiple Sclerosis -- The COMBO-MS Trial

University of Michigan
| Michigan
Tiffany J. Braley, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Essure® and Tubal Ligation to Prevent Pregnancy

Yale University
| Connecticut
Aileen M. Gariepy, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Creating Recommendations on Types of Data to Present in Patient-Reported Outcome Measure Development Studies

University of Michigan
| Michigan
Joel Joseph Gagnier, PhD ND, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Developing New Statistical Methods for Clinical Studies Where Patients Choose Their Treatments

Yale University
| Connecticut
Denise Esserman, MS, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

HealthCore-Anthem Research Network (HCARN)

Health Core, Inc.
| Delaware
Kevin Haynes, MS, PhrmD
Project Status:
Completed
Project Type:
PCORnet® Initiative on Health Plan/System Data Partnerships (A Stepwise Approach to Collaboration)

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