Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 130 results

Project Title
Project Status
Project Type

Using a Smartphone Program to Help Patients Manage Symptoms of Serious Mental Illness

University of Washington
| Washington
Dror Ben-Zeev, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Implementation Project (Limited Competition D&I PFA)

Pragmatic Comparative Effectiveness Using Sequential Multiple Assignment Randomized Trials

University of Rochester
| New York
Abdus Wahed, PhD, MS, MA
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Developing New Methods for Mediation Analysis Using Machine Learning

New York University
| New York
Ivan Diaz, PhD, MPH, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Using Machine Learning to Measure Treatment Effects over Time

Rutgers, The State University of New Jersey
| New Jersey
Liangyuan Hu, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Implementing Matching of Patients to Mental Healthcare Therapists’ Strengths

University of Massachusetts Amherst
| Massachusetts
Michael Constantino, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Implementation Project (Limited Competition D&I PFA)

Supporting Families' Treatment Decisions with Evidence on Treatment of Urea Cycle Disorders

Children's National Health System
| District of Columbia
Nicholas Ah Mew, MD
Project Status:
In progress; Recruitment not applicable
Project Type:
Dissemination Project (Limited Competition D&I PFA)

Emerging Technologies and Therapeutics Reports: Narrative Review and Evidence Mapping of Artificial Intelligence in Clinical Care

RAND Corporation
| California
Project Status:
Completed
Project Type:
Other Evidence Products
Has Results

Protecting the Well-Being of Healthcare Workers during the COVID-19 Pandemic -- The COVER-HCW Project

RAND Corporation
| California
Lisa S. Meredith, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Expanding the Use of a School-Based Program to Improve Executive Functioning among Students with Symptoms of Autism Spectrum Disorder or Attention Deficit/Hyperactivity Disorder

University of Colorado Denver
| Colorado
Laura G. Anthony, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Implementation Project (Limited Competition D&I PFA)
Has Results

Self-Management in Older Adults with Chronic Heart Failure -- The iCOACH Study

University of Arkansas for Medical Sciences
| Arkansas
Judy Weber, PhD, RD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Expanding Implementation of Family Problem-Solving Therapy for Teens with Traumatic Brain Injury

Cincinnati Children's Hospital Medical Center
| Ohio
Shari L. Wade, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Implementation Project (Limited Competition D&I PFA)

Expanding the Use of IMPaCT: A Community Health Worker Program

University of Pennsylvania Perelman School of Medicine
| Pennsylvania
Shreya Kangovi, MD, MS
Project Status:
Completed
Project Type:
Implementation Project (Limited Competition D&I PFA)
Has Results

Stroke and Blood Clot Risk in Transgender Women Taking Hormones

Emory University
| Georgia
Michael Goodman, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Help Sexual and Gender Minority Men Who Have Been Sexually Abused Reduce Depression and Increase Mental Health Treatment Engagement

Yale University
| Connecticut
Joan M. Cook, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Universal versus Focused Screening for Depression among Teens in High School -- The SHIELD Trial

Penn State Health Milton S. Hershey Medical Center
| Pennsylvania
Deepa L. Sekhar, MD, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Programs to Reduce Unsafe Opioid Prescribing and Improve Outcomes among People Who Are Injured at Work -- The WOW Study

University of Washington
| Washington
Gary Franklin, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Two Treatments for Depression among Patients with Advanced Heart Failure

Cedars-Sinai Health System
| California
Waguih William IsHak, MD, FAPA
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Supporting Behavioral Health Home Approaches for Improving Patients’ Health and Wellness

UPMC Center for High ValueHealth Care
| Pennsylvania
James M. Schuster, MD, MBA
Project Status:
Completed
Project Type:
Implementation Project (Limited Competition D&I PFA)
Has Results

Testing a Standard Approach to Match Patients with Addiction to Treatment Based on Their Needs -- The PCAST Study

RTI International
| North Carolina
Tami L. Mark, PhD, MBA
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Does a Decision Aid Help Older Adults with Chronic Kidney Disease Choose Treatment? -- The DART Study

Trustees of Tufts College
| Massachusetts
Keren Ladin, PhD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Meditation versus Medicine for Patients with Anxiety Disorders

Georgetown University Medical Center
| District of Columbia
Elizabeth Hoge, MD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Ways to Treat Insomnia among Black Women

Boston University
| Massachusetts
Lynn Rosenberg, ScD, MS, and Eric Zhou, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Understanding the Effect of Gender-Affirming Hormone Therapy on Sexual Health and Depression for Transgender Adults

Brigham and Women's Hospital
| Massachusetts
Sari L. Reisner, ScD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing the Effectiveness of Three Treatments for Reducing Fatigue among Patients with Multiple Sclerosis -- The COMBO-MS Trial

University of Michigan
| Michigan
Tiffany J. Braley, MD, MS
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

Comparing Ways to Help Primary Care Providers Prescribe Opioids Safely

University of Pittsburgh
| Pennsylvania
Kevin Kraemer, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®

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