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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
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Displaying 1 - 25 of 212 results

Project Title
Project Status
Project Type

Rapid Reversal of Acute Suicidal Depression across the Lifespan: A Pragmatic Comparative Effectiveness Trial of Electroconvulsive Therapy vs. Intravenous Ketamine Treatment

Brigham and Women's Hospital
| Massachusetts
Amit Anand, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD

Massachusetts General Hospital
| Massachusetts
Andrew Nierenberg, MD
Project Status:
Awarded; Contract pending
Project Type:
Research

A TriaL ComparIng the EffectiVEness and ToleraBility of MEdicaTions in Older Adults with STablE Angina and Multiple ChRonic Conditions: LIVE BETTER

Yale University
| Connecticut
Michael Nanna, MD, MHS
Project Status:
In progress; Recruiting
Project Type:
Research

Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

University of Pennsylvania
| Pennsylvania
Mucio Delgado, MD, MS
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Using Technology to Improve Maternal Mental Health and Substance Use Disorder Screening and Treatment

Medical University of South Carolina
| South Carolina
Constance Guille, MD, MSCR
Project Status:
In progress; Recruiting
Project Type:
Research

Preventing Suicidal Behavior with Diverse High-Risk Youth in Acute Care Settings

Johns Hopkins University
| Maryland
Holly Wilcox, PhD, MA
Project Status:
Awarded; Contract pending
Project Type:
Research

LIVE-SMART: Liver Cirrhosis Interventions for Fall prevention - A Sequential, Multiple Assignment Randomized Trial

University of Michigan
| Michigan
Elliot Tapper, MD
Project Status:
In progress; Recruiting
Project Type:
Research

Using a Smartphone Program to Help Patients Manage Symptoms of Serious Mental Illness

University of Washington
| Washington
Dror Ben-Zeev, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Implementation Project (Limited Competition D&I PFA)

Comparing Healthcare Visit Recording and Open Notes to Improve the Chronic Illness Care Experience for Older Adults (The CHRONICLE Trial)

Trustees of Dartmouth College
| New Hampshire
Paul Barr, PhD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research

Pragmatic Comparative Effectiveness Using Sequential Multiple Assignment Randomized Trials

University of Pittsburgh at Pittsburgh
| Pennsylvania
Abdus Wahed, PhD, MS, MA
Project Status:
Awarded; Contract pending
Project Type:
Research

Causal Mediation Analysis with Machine Learning to Understand Comparative Treatment Effects

New York University
| New York
Ivan Diaz, PhD, MPH, MS
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Robust Longitudinal Causal Inference Methods with Machine Learning

Rutgers, The State University of New Jersey
| New Jersey
Liangyuan Hu, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Research

Implementing Matching of Patients to Mental Healthcare Therapists’ Strengths

University of Massachusetts Amherst
| Massachusetts
Michael Constantino, PhD
Project Status:
In progress; Recruitment not applicable
Project Type:
Implementation Project (Limited Competition D&I PFA)

Efficacy of Pharmacologic Management of ADHD in Children and Youth with Autism Spectrum Disorder

The Research Institute at Nationwide Children's Hospital
| Ohio
Daniel Coury, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Pragmatic Trial to Enhance Quality Safety, and Patient Experience in COPD -- EQuiP COPD

VA Puget Sound Health Care System
| Washington
David Au, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Community-Based, Family-Centered, Trauma-Informed Approach to Timely Detection and Management of Early Postpartum Hypertension

Yale School of Public Health
| Connecticut
Rafael Perez-Escamilla, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Expanding First-Line Options for Depression & Matching Treatments: Hatha Yoga vs. Behavioral Therapy

Massachusetts General Hospital
| Massachusetts
Louisa Sylvia, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Three Ways to Help People Quit Smoking

University of Florida
| Florida
Jesse Dallery, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Improving the Health of Parents and Their Adolescent and Transition-Age Youth With IDD

The University of North Carolina at Chapel Hill
| North Carolina
Kathleen Thomas, MPH, PHD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide School-Based Mental Health Screening to Improve Access to Treatment for Black Students

University of Florida
| Florida
Joni Splett, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Suicide Prevention Programs for Young People following an ER Visit

University of California, Los Angeles
| California
Joan Asarnow, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Preventing Suicide among Sexual and Gender Diverse Youth

UT Southwestern Medical Center
| Texas
Elizabeth Arnold, PhD, MSW
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Two Ways to Prevent Suicide among Autistic Youth

The University of North Carolina at Chapel Hill
| North Carolina
Brenna Maddox, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Prevent Suicide among Alaska Native Young People -- The BeWeL Study

RAND Corporation
| Pennsylvania
Elizabeth D'Amico, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide Palliative Care for Patients Who Are in the Hospital with Acute Myeloid Leukemia

Massachusetts General Hospital
| Massachusetts
Areej El-Jawahri, MD
Project Status:
In progress; Recruiting
Project Type:
Research

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