Explore Our Portfolio

Search a repository of PCORI-funded comparative clinical effectiveness research (CER) studies, as well as projects that seek to encourage engagement in research, disseminate and implement PCORI-funded research findings, and improve the nation's capacity to conduct patient-centered CER, among others. Learn more about the Portfolio

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Status Project Status View definitions of the life cycle of an awarded project View Glossary
State State The state where the project originates, or where the primary institution or organization is located. View Glossary
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Health Condition Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Population Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Intervention Strategy Intervention Strategies PCORI funds comparative clinical effectiveness research (CER) studies that compare two or more options or approaches to health care, or that compare different ways of delivering or receiving care. View Glossary
Year Awarded Year Awarded The year that funding for the project was approved, or the year the proposal received a notice of award. View Glossary
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Displaying 1 - 25 of 40 results

Project Title
Project Status
Project Type

Sequential Multiple Assignment Randomized Trial for Bipolar Depression: SMART-BD

Massachusetts General Hospital
| Massachusetts
Andrew Nierenberg, MD
Project Status:
In progress; Not yet recruiting
Project Type:
Research

Comparing Two Ways to Screen People for Anxiety, Substance Use Disorders, and Intimate Partner Violence before and after Giving Birth -- The LTWP Study

Medical University of South Carolina
| South Carolina
Constance Guille, MD, MSCR
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Four Ways to Reduce Pregnancy Complications among Black Mothers -- The ACURE4Moms Study

University of North Carolina at Chapel Hill School of Medicine
| North Carolina
Jennifer Tang, MD, MS
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Ways to Provide Maternal Mental Health Treatment to Women Who Are Black or of African Descent Living in Washington, DC

Children's Research Institute
| District of Columbia
Catherine Limperopoulos, PhD
Project Status:
In progress; Recruiting
Project Type:
Research

Comparing Two Ways to Provide Pregnant Women with Prenatal Care and Treatment for Opioid Use Disorder

Yale University School of Medicine
| Connecticut
Ariadna Forray
Project Status:
In progress; Data collected
Project Type:
Research
Has Results

Comparing Two Ways to Provide Enhanced Prenatal Care to Improve Health in Mothers and Babies -- The EMBRACE Study

University of California, San Francisco
| California
Miriam Kuppermann, PhD, MPH
Project Status:
In progress; Recruiting
Project Type:
Research
Has Results

Stroke and Blood Clot Risk in Transgender Women Taking Hormones

Emory University
| Georgia
Michael Goodman, MD, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Ways to Help Sexual and Gender Minority Men Who Have Been Sexually Abused Reduce Depression and Increase Mental Health Treatment Engagement

Yale University
| Connecticut
Joan M. Cook, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research

Comparing Two Methods to Deliver a Health Education Program for Pregnant Women Treated for Opioid Use Disorder in Rural Kentucky -- The PATH Home Trial

University of Kentucky Research Foundation
| Kentucky
Wendy Hansen, MD
Project Status:
In progress; Enrollment complete
Project Type:
Research

Comparing Two Ways to Provide Treatment for Pregnant Women with Opioid Use Disorder

Trustees of Dartmouth College
| New Hampshire
Sarah Lord, PhD
Project Status:
In progress; Data collected
Project Type:
Research
Has Results

Comparing Two Programs for Managing Long-Term Health Problems for People with Lived Experience of Mental Illness

Dartmouth-Hitchcock Clinic
| New Hampshire
Sarah Pratt, PhD^
Project Status:
In progress; Recruiting
Project Type:
Research

Using a New Survey to Learn About Women’s Experiences with Hospital Care for Childbirth

Cedars-Sinai Medical Center
| California
Kimberly D. Gregory, MD, MPH
Project Status:
Completed
Project Type:
Implementation Project (Limited Competition D&I PFA)
Has Results

Evaluating Hormone Treatments for Women at Increased Risk for Preterm Birth -- The EPPPIC Study

University of York (United Kingdom)
| N/A
Lesley Stewart, PhD, MSc
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Two Approaches for Delivering Group Medical Visits for Patients with Diabetes

University of Colorado Denver
| Colorado
Bethany M. Kwan, PhD, MSPH
Project Status:
Completed; PCORI Public and Professional Abstracts Posted
Project Type:
Research
Has Results

New Methods to Improve Data Accuracy in Studies Using Electronic Health Record Data

Vanderbilt University Medical Center
| Tennessee
Bryan E. Shepherd, PhD; Pamela A. Shaw, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Does Treating Genital Herpes during Pregnancy Improve Birth Outcomes?

Kaiser Foundation Research Institute
| California
De-Kun Li, MD, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Standard and Short Online Mindfulness Therapy Programs for Improving Well-Being -- The Healthy Mind Healthy You Study

Massachusetts General Hospital
| Massachusetts
Andrew A. Nierenberg, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Medicines for Long-Term Treatment of Bipolar Disorder

University of New Mexico Health Sciences Center
| New Mexico
Christophe G. Lambert, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Testing the Effectiveness of Adding Group Therapy to Home Visiting Services on Reducing Postpartum Depression in Women with Low Incomes

Northwestern University
| Illinois
Darius Tandon, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Comparing Three Ways to Increase Physical Activity in Patients with Depression and Cardiovascular Disease -- The Healthy Hearts Healthy Minds Study

Massachusetts General Hospital
| Massachusetts
Andrew A. Nierenberg, MD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®

Helping People with Serious Mental Illness Stop Smoking

Massachusetts General Hospital
| Massachusetts
Eden Evins, MD, MPH
Project Status:
In PCORI Peer-Review Process
Project Type:
Research
Has Results

Matching Patients with Therapists to Improve Mental Health Care

University of Massachusetts Amherst
| Massachusetts
Michael J. Constantino, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Looking at the Effects of Antibiotic Use on Childhood Obesity and Growth -- The PCORnet® Antibiotics Study

Harvard Pilgrim Health Care, Inc.
| Massachusetts
Jason Block, MD, MPH^
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research, Research Conducted Using PCORnet®
Has Results

Comparing Two Telehealth Approaches for Treating Complex Psychiatric Disorders in Primary Care -- The SPIRIT Study

University of Washington
| Washington
John C. Fortney, PhD
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research
Has Results

Effect of High-Deductible Health Plans on Healthcare Use and Out-of-Pocket Costs for People with Bipolar Disorder

Harvard Pilgrim Health Care ,Inc.
| Massachusetts
James Franklin Wharam, MB, BCh, BAO, MPH
Project Status:
Completed; PCORI Public and Professional Abstracts, and Final Research Report Posted
Project Type:
Research

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