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PCORI's Online System opened on May 2, 2023, for the submission of Letters of Intent (LOI) for the following PCORI Funding Announcements (PFAs). LOIs are due on May 31 by 5:00 pm ET, and applications are due August 29 by 5:00 pm ET.

Health System Strategies to Address Disparities in Hypertension Management & Control

This PFA is soliciting applications for large randomized controlled trials that respond to the following question: What is the comparative effectiveness of health system strategies to improve hypertension control for populations experiencing disparities in hypertension control and associated health outcomes, e.g., Black, Hispanic, rural, and/or uninsured individuals?

Learn more about this PFA and watch the virtual applicant town hall.

Comparative Effectiveness of Novel Pharmacologic and Evidence-Based Nonpharmacologic Treatments for Migraine Prevention

This PFA is soliciting applications for rigorous, large-scale pragmatic trials that compare newly available pharmacologic and/or evidence-based nonpharmacologic treatments for the prevention of migraine. PCORI is interested in studies that compare emerging pharmacological options and studies that examine the comparative effectiveness of evidence-based nonpharmacological options for migraine prevention.

Learn more about this PFA and watch the virtual applicant town hall.

Phased Large Awards for Comparative Effectiveness Research (PLACER)

This PFA is seeking applications for high-quality comparative clinical effectiveness research studies that will address critical decisions faced by patients, caregivers, clinicians, and stakeholders across the health and healthcare community and for which there is insufficient evidence. Proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions, and compare interventions that already have evidence of efficacy or are in widespread use.

Learn more about this PFA and watch the virtual applicant town hall.

Broad Pragmatic Studies

This PFA is soliciting applications for comparative clinical effectiveness research (CER) studies that align with at least one of PCORI's National Priorities for Health. For this 2023 standing PFA, new Topic Themes have also been introduced and applicants have the option to choose up to three Topic Themes, based on how their proposed research aligns with the themes.

Cycle 2 2023 includes the addition of a Category 3 option to support studies using PCORnet^®, the National Patient-Centered Clinical Research Network, to advance PCORI's National Priorities for Health. Find out more about Category 3 here.

Learn more about this PFA and watch the virtual applicant town hall. In addition, watch the virtual workshop about the new Category 3 option.

Improving Methods for Conducting Patient-Centered Outcomes Research

Through this PFA, PCORI is seeking to fund studies that address high-priority methodological gaps in patient-centered outcomes research (PCOR) and CER, as well as projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by PCOR/CER studies. The PFA includes four areas of programmatic priorities.

Learn more about this PFA

Advancing the Science of Engagement

The PFA is seeking to fund studies that build an evidence base on engagement in research, including measures to capture structure/context, process, and outcomes of engagement in research, techniques that lead to effective engagement in research, and how effective engagement techniques should be modified and resourced for different contexts, settings, and communities to ensure equity in engagement and research.

Learn more about this PFA register to attend a virtual applicant town hall on May 23.

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Posted: February 13, 2023; Updated: May 2, 2023