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PCORI's Online System opened on May 7, 2024, for the submission of Letters of Intent (LOI) for several research PCORI Funding Announcements (PFA), which will fund proposals for high-quality patient-centered comparative clinical effectiveness research (CER). Learn more about them below.

PCOR News Release: PCORI offers up to $200 million for new health research on substance use, rare diseases

LOIs are due on June 4, 2024 and applications are due on Sept. 4, 2024.


Addressing Rare Diseases

This topical PFA is seeking proposals to address patient-centered CER questions that fill important rare disease research gaps. Applications addressing critical decisional dilemmas that span multiple rare diseases are encouraged. PCORI is particularly interested in submissions that address the following special areas of emphasis: approaches to symptom management for individuals with rare disease; approaches for timely diagnosis of rare diseases; and approaches to improving care delivery for individuals with rare diseases.


Addressing Substance Use

This topical PFA is seeking to fund high-quality patient-centered CER studies that focus on addressing substance use/misuse and substance use disorders. PCORI is particularly interested in submissions that address the following special areas of emphasis: evidence-based strategies to advance equity in the prevention and treatment of substance use disorders; evidence-based interventions for overdose prevention; and strategies to reduce nicotine and tobacco use in disproportionally affected populations.


Phased Large Awards for Comparative Effectiveness Research (PLACER)

This PFA is seeking research study proposals that address critical decisions faced by patients, caregivers, clinicians and stakeholders across the health and healthcare community and for which there is insufficient evidence. The proposed trials should address critical decisional dilemmas that require important new evidence about the comparative clinical effectiveness of available interventions. They should also compare interventions that already have robust evidence of efficacy and are in current use.


Advancing the Science of Engagement in Research

This PFA is seeking to fund studies that build an evidence base on engagement in research, including measures to capture structure/context, process and outcomes of engagement in research; techniques that lead to effective engagement in research; and how effective engagement techniques should be modified and resourced for different contexts, settings and communities to ensure equity in engagement and research.


Broad Pragmatic Studies

This PFA will fund proposals for high-quality patient-centered CER studies that align with at least one of the PCORI National Priorities for Health described within the PFA. Applicants have the option to choose up to three of 12 Topic Themes, based on how their proposed research aligns with the themes. Through this PFA, PCORI will support research studies with direct costs up to a maximum of $12 million.

PCORI has also identified four special areas of emphasis -- Post-Traumatic Stress Disorder, Improving Health and Quality of Life in Down Syndrome, Peripheral Arterial Disease, and Functional Sensory Impairment in Older Adults -- to support innovative, high-impact studies that fit clearly within our core mission of patient-engaged and patient-centered CER.

Starting with Cycle 2 2024, the BPS PFA includes a new initiative through which applicants may propose coverage of structured mentorship activities for early- or mid-career investigators, or investigators whose lived experiences, perspectives, or backgrounds are underrepresented in research. As detailed further in the PFA, applicants must address specific criteria for potential funding. PCORI funding for requested structured mentorship activities is not assured.


Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research

Through this PFA, PCORI is seeking to fund studies that address high-priority methodological gaps in patient-centered CER. This PFA will also fund studies that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies. The PFA includes four areas of programmatic priorities.


Long-term Follow-up to Improve Patient-Centered Outcomes of PCORI-Funded Comparative Clinical Effectiveness Research

Through this PFA, which is limited to currently active PCORI CER awards only, PCORI is seeking to fund high-quality patient-centered CER studies that focus on long-term follow-up of patient-centered outcomes. Long-term follow-up allows the opportunity to examine later effects of therapeutic interventions, treatments and programs providing a more comprehensive view of intervention benefits and harms.


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Posted: March 18, 2024; Updated: May 17, 2024

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