On May 7, 2024, PCORI will begin accepting Letter of Intent (LOI) submissions for the Addressing Substance Use Topical PCORI Funding Announcement (PFA) under Cycle 2 2024.


A close-up photo of a hand with tobacco products, a glass of alcohol, and illicit drug pills on a table.
Among those aged 12 or older in the United States, around 60 percent reported current use of tobacco products, nicotine, alcohol or an illicit drug in 2022. Nationally, over 48 million people aged 12 or older were diagnosed with a substance use disorder in 2022.

This Topical PFA will seek to fund high-quality patient-centered comparative clinical effectiveness research (CER) studies that are focused on addressing substance use/misuse and substance use disorders.

Applications may propose CER studies of prevention, screening, harm reduction, treatment and recovery approaches for substance use/misuse and substance use disorders at the individual, community or systems level to improve patient-centered substance-use-related outcomes. At least one primary outcome must be focused on substance use.

PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAEs).

  • Evidence-Based Strategies to Advance Equity in the Prevention and Treatment of Substance Use Disorders.
  • Evidence-Based Interventions for Overdose Prevention.
  • Strategies to Reduce Nicotine and Tobacco Use in Disproportionally Affected Populations.

The purpose of identifying these SAEs is to encourage submissions to these areas, not to limit submissions to these topics. Applicants addressing an SAE should identify the area that is best associated with their research approach.

Learn more about this PFA and attend a virtual applicant town hall on May 17.

This PFA will open on May 7 and LOIs will be due on June 4 by 5 pm (ET).

Posted: February 23, 2024

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