Notice of Upcoming PCORI Funding Announcement

The Patient-Centered Outcomes Research Institute (PCORI) intends to release a PCORI Funding Announcement (PFA) on May 2, 2023, seeking to fund studies that build an evidence base on engagement in research, including:

• Measures to capture structure/context, process, and outcomes of engagement in research
• Techniques that lead to effective engagement in research
• How effective engagement techniques should be modified and resourced for different contexts, settings, and communities to ensure equity in engagement and research

This preannouncement is provided to allow potential applicants additional time to identify collaborators, obtain stakeholder input on potential studies, and create responsive, high-quality proposals.

Over the past decade, PCORI has transformed how research is conducted by requiring the engagement of patients, caregivers, and stakeholders from across the broader healthcare community. Engagement in research is defined as the meaningful involvement and partnership of stakeholders throughout the research process—from planning to conducting the study, to ultimately disseminating study results.

Much has been learned about engagement in research from PCORI’s investments, yet significant evidence gaps remain. There is presently no consensus on how to define or measure engagement, and there has been little systematic study of which engagement techniques are most effective. Methods for engaging and facilitating the inclusion of historically underrepresented populations as study partners is a further critical gap.

Through 10 years of funding engaged research, PCORI has learned that engagement is a complex intervention, and there is not yet an in-depth understanding of how engagement in research produces its effects. Understanding how engagement supports successful research will advance PCORI’s National Priorities for Health. Consistent with complex health intervention frameworks and the Donabedian Structure/Context-Process-Outcomes framework, studies must first define the activities and behaviors that engagement entails—and measure them—to understand which components predict success and the causal mechanisms underlying them.

Research Initiative Highlights

PCORI’s PFA on the Science of Engagement will solicit applications that focus on:

• Development and validation of measures to capture structure/context, process, and outcomes of engagement, for both stakeholders and investigators
• Development and testing of engagement techniques to generate evidence on the most effective engagement approaches, particularly for underrepresented populations, and how effectiveness varies by context

Initial funding will primarily focus on measure development and validation, particularly rapid measure development, leveraging opportunities to support teams that have already begun measure development work. Applicants can also adapt and validate preexisting measures created for different contexts (e.g., community-based participatory research, engagement in healthcare delivery). A smaller number of early awards will test engagement techniques using a combination of limited existing validated measures of engagement and measures of other research outcomes (e.g., participant recruitment and retention, diversity, equity, and inclusion outcomes). PCORI anticipates nine funding cycles for this initiative, with this cycle being the third. The focus of subsequent PFAs will be updated as the evidence base grows.