The Broad PCORI Funding Announcements (PFAs) seek investigator-initiated applications for patient-centered comparative clinical effectiveness research (CER) projects aligned with our priority areas for research. This PFA covers the following four priority areas:

• Addressing Disparities (AD)
• Assessment of Prevention, Diagnosis, and Treatment Options (APDTO)
• Communication and Dissemination Research (CDR)
• Improving Healthcare Systems (IHS)

Applications should address needs of patients, caregivers, clinicians, and other healthcare stakeholders in making personalized clinical decisions across a wide range of conditions, populations, and treatments. Note: In general, PCORI will not cover costs for interventions that are being compared in the proposed study.

These broad areas encompass the patient-centered comparative clinical effectiveness research we support. As our work progresses and we engage with a broad range of patients, caregivers, clinicians, and other healthcare stakeholders, we may develop additional national priorities for research.

Our National Priorities for Research and Research Agenda is a framework to guide our funding of comparative clinical effectiveness research that will give patients and those who care for them the ability to make better-informed health decisions. The framework was developed by workgroups of our Board of Governors, members of our Methodology Committee, and staff. It was revised in response to public comments and accepted by the Board on May 21, 2012.