The Patient-Centered Outcomes Research Institute (PCORI is seeking to fund large randomized controlled trials (RCTs) comparing health system strategies to improve hypertension control and health outcomes for populations experiencing disparities in outcomes, e.g., Black, Hispanic, rural, and/or uninsured individuals.

Awards Announcement

Funding awards under this PFA are expected to be announced in March 2024.

Hypertension affects almost half of US adults, with the highest prevalence among non-Hispanic Black men and women. Despite hypertension’s treatability, most US adults with hypertension do not have their blood pressure under control, especially people of color, those without access to care or health insurance, and individuals living in rural areas. Health systems factors including the delayed identification of high-risk patients, insufficient linkage to treatment and services, and/or a failure to initiate or intensify treatment when needed may inhibit patients’ ability to control their blood pressure. Implicit bias among healthcare providers may contribute to treatment inertia; inhibit timely, appropriate care delivery; and encumber patient-provider communication, further contributing to poor health outcomes for patients.

National organizations have identified several effective health systems strategies—including practice facilitation, team-based care, health coaching, and home blood pressure monitoring—to be effective for improving rates of hypertension control when implemented as part of multicomponent, multilevel health systems strategies. Although the evidence base for these health systems strategies is robust, questions remain about the optimal health system strategies to eliminate disparities in hypertension control; strategies for the integration of and communication with community-based team members (nurse, pharmacist, community health worker); models for the provision of simplified pharmacotherapy regimens or free or low-cost medications; and the impact of remote care delivery on the initiation and intensification of treatment, patient engagement and experience, and clinical outcomes, especially in historically excluded, under-researched, and/or under-resourced populations and safety net healthcare settings.

This Targeted PCORI Funding Announcement will solicit applications that respond to the following question:

What is the comparative effectiveness of health system strategies to improve hypertension control for populations experiencing disparities in hypertension control and associated health outcomes, e.g., Black, Hispanic, rural, and/or uninsured individuals?

The reissued funding announcement will emphasize the following:

Applicants will be asked to propose studies in adults with high blood pressure that is not controlled, especially those in underserved, underrepresented, or historically excluded populations, including Black, Hispanic, rural, and/or uninsured individuals. Studies that provide knowledge about an intervention’s impact on multiple subgroups (i.e., studies that are adequately powered for evaluating heterogeneity of treatment effects) are strongly encouraged.

Interventions must be health system strategies, including but not limited to practice facilitation and redesign; team-based care; support for medication access and adherence (e.g., fixed-dose combinations, simplified medication regimens, 90-day prescriptions, use of mail-order pharmacies); telehealth; risk communication and shared decision making tools; community linkage, referral, or service provision; and community health workers. PCORI is especially interested in studies comparing care delivery strategies designed to address therapeutic inertia and patient-centered strategies to improve medication access and adherence.

Applicants must propose studies with blood pressure (e.g., change in average systolic blood pressure or ability to control blood pressure) at 12 months or later from initiation of intervention as a primary outcome. Research projects are strongly encouraged to conduct periodic outcome assessments, including long-term follow-up periods at or greater than 18 months from the primary outcome (i.e., 30 months from intervention initiation).

For questions regarding this funding announcement, please reach out to [email protected].

Download Full Announcement

Key Dates

Online System Opens
May 2, 2023
Applicant Town Hall
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View Event
Letter of Intent Deadline
May 31, 2023; 5:00 pm ET
Letter of Intent Status Notification
June 27, 2023
Application Deadline
August 29, 2023; 5:00 pm ET
Merit Review
November 2023
Awards Announced
March 2024
Earliest Start Date
July 2024

Funds and Project Period

Funds Available Up To
$50 million
Total Direct Costs
Up to $15 million
Maximum Project Period
Up to 5 years

Tags

Year
Health Conditions Health Conditions These are the broad terms we use to categorize our funded research studies; specific diseases or conditions are included within the appropriate larger category. Note: not all of our funded projects focus on a single disease or condition; some touch on multiple diseases or conditions, research methods, or broader health system interventions. Such projects won’t be listed by a primary disease/condition and so won’t appear if you use this filter tool to find them. View Glossary
Populations Populations PCORI is interested in research that seeks to better understand how different clinical and health system options work for different people. These populations are frequently studied in our portfolio or identified as being of interest by our stakeholders. View Glossary
Award Types
Cycle