This PCORI Funding Announcement (PFA) seeks to fund large-scale implementation projects that promote the uptake of peer-reviewed findings from specific, high-priority PCORI-funded research topics in the context of the body of related evidence. This PFA is an open competition opportunity for PIs to propose implementation projects that move evidence toward practical use in improving health care and health outcomes. Applicants may propose projects with budgets up to $2.5 million in total costs.

Note that the topics selected as the focus for implementation may change from cycle to cycle.

Evidence Eligible as the Focus of Implementation under this PFA:

Each release of this PFA will identify as the focus of implementation selected published, peer-reviewed evidence emerging from selected areas of PCORI’s research investment.

For the Cycle 1 2022 PFA, PCORI has identified the following four areas of eligible evidence:

Projects to Be Funded under this PFA

PCORI seeks to fund implementation projects that incorporate active, multicomponent strategies that will lead to uptake and integration of PCORI-funded evidence in real-world practice settings. Implementation strategies should target specific end-users with a clear interest in—and who are able to benefit from—the evidence. Proposed implementation projects will adapt findings as needed to facilitate uptake in the proposed settings and accomplish scale-up (to reach larger numbers) and/or scale-out (to reach broader audiences, including diverse populations and settings). Applicants must demonstrate commitment and buy-in from proposed implementation sites—including frontline staff critical to the success of the project as well as leadership—such that they provide a supportive context and culture for undertaking the proposed project. In addition, projects should involve regional and national stakeholder organizations positioned to extend impact to broader venues. Applications must be guided by an established conceptual model or framework and, where possible, by evidence regarding effective strategies for implementing evidence-based practices and interventions. Additionally, applications must include a rigorous evaluation plan that documents the successful execution of the implementation strategy and the impact of the implementation project on health care and health outcomes as feasible and appropriate within the project scope.

Eligible Applicants

This is an Open Competition funding opportunity that seeks to draw on the expertise, creativity, and capacity of a broad applicant pool, including implementation experts and diverse stakeholder partners. As such, PCORI does not require applicants to have been associated with the PCORI-funded studies described above, nor need they have received any previous PCORI funding.

Organizations: Private-sector research organizations, including any nonprofit or for-profit organization; public-sector research organizations, including any university or college hospital or healthcare system; any laboratory or manufacturer; or any unit of local, state, or federal government may submit applications. The Internal Revenue Service must recognize all US applicant organizations. Nondomestic components of organizations based in the US and foreign organizations may apply, as long as there is demonstrable benefit to the US healthcare system and US efforts in the area of patient-centered research. Organizations may submit multiple funding applications. Individuals may not apply.