Implementation of Findings from PCORI's Major Research Investments -- Cycle 3 2021
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This PCORI Funding Announcement (PFA) seeks to fund large-scale implementation projects that promote the uptake of peer-reviewed findings from specific, high-priority PCORI-funded research topics in the context of the body of related evidence. This PFA is an open competition opportunity for PIs to propose implementation projects that move evidence toward practical use in improving health care and health outcomes. Applicants may propose projects with budgets up to $2.5 million in total costs.
Starting in Cycle 2 2021, this PFA will be released each cycle. Note that the topics selected as the focus for implementation may change from cycle to cycle.
Evidence Eligible as the Focus of Implementation Under this PFA
Each release of this PFA will identify as the focus of implementation selected published, peer-reviewed evidence emerging from selected areas of PCORI’s research investment.
For the Cycle 3 2021 PFA, PCORI has identified the following four areas of eligible evidence:
- Obesity Treatment in Primary Care Settings (New Topic for Cycle 3 2021)
In Spring 2014, PCORI issued a targeted funding announcement for pragmatic clinical trials to evaluate obesity treatment options in primary care for underserved populations. Two completed PCORI-funded studies have demonstrated the effectiveness of practical intensive lifestyle interventions that led to weight loss. These interventions were tested with patient groups that disproportionately experience obesity, including racial and ethnic minorities, people with lower socioeconomic status, and rural residents. These studies include:
- Publication: Weight Loss in Underserved Patients — A Cluster-Randomized Trial; read more about the PCORI-funded study here.
- Publication: Effect of Behavioral Therapy With In-Clinic or Telephone Group Visits vs In-Clinic Individual Visits on Weight Loss Among Patients With Obesity in Rural Clinical Practice: A Randomized Clinical Trial; read more about the PCORI-funded study here.
- Nonsurgical treatment options can improve or eliminate symptoms for women with urinary incontinence (UI).
Millions of women experience urinary incontinence; however, a majority do not receive treatment. A recent systematic review update on this topic found that several nonsurgical treatments for urinary incontinence can help.
- Publication: Pharmacologic and Nonpharmacologic Treatments for Urinary Incontinence in Women; read more about the PCORI-funded study here.
- Several kinds of therapy and medicines can reduce or stop symptoms for people with posttraumatic stress disorder (PTSD).
Findings from a recent systematic review update, which support the strength of evidence for specific treatment approaches for PTSD, underscore the potential for improving patient-centered outcomes through the implementation of effective treatment.
- Publication: Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update; read more about the PCORI-funded study here.
- The use of narrow-spectrum versus broad-spectrum antibiotics to treat children’s acute respiratory tract infections (ARTIs).
Current guidelines generally recommend the use of narrow-spectrum antibiotics, such as amoxicillin, as first-line treatment for ARTIs in children, subject to local conditions with respect to antibiotic resistance. A PCORI-funded study highlights the benefits of using narrow-spectrum antibiotics when possible. Consistent prescription of narrow-spectrum antibiotics as first-line treatment for these children has the potential to improve the quality of life for children, lowering the incidence of treatment-associated side effects, and for their caregivers.
- Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections; read more about the PCORI-funded study here.
*More detailed descriptions of the full set of topics will be included in the PFA.
Projects to Be Funded under this PFA
PCORI seeks to fund implementation projects that incorporate active, multicomponent strategies that will lead to uptake and integration of PCORI-funded evidence in real-world practice settings. Implementation strategies should target specific end-users with a clear interest in—and who are able to benefit from—the evidence. Proposed implementation projects will adapt findings as needed to facilitate uptake in the proposed settings and accomplish scale-up (to reach larger numbers) and/or scale-out (to reach broader audiences, including diverse populations and settings). Applicants must demonstrate commitment and buy-in from proposed implementation sites—including frontline staff critical to the success of the project as well as leadership—such that they provide a supportive context and culture for undertaking the proposed project. In addition, projects should involve regional and national stakeholder organizations positioned to extend impact to broader venues. Applications must be guided by an established conceptual model or framework and, where possible, by evidence regarding effective strategies for implementing evidence-based practices and interventions. Additionally, applications must include a rigorous evaluation plan that documents the successful execution of the implementation strategy and the impact of the implementation project on health care and health outcomes as feasible and appropriate within the project scope.
This is an Open Competition funding opportunity that seeks to draw on the expertise, creativity, and capacity of a broad applicant pool, including implementation experts and diverse stakeholder partners. As such, PCORI does not require applicants to have been associated with the PCORI-funded studies described above, nor need they have received any previous PCORI funding.
Organizations: Private-sector research organizations, including any nonprofit or for-profit organization; public-sector research organizations, including any university or college hospital or healthcare system; any laboratory or manufacturer; or any unit of local, state, or federal government may submit applications. The Internal Revenue Service must recognize all US applicant organizations. Nondomestic components of organizations based in the US and foreign organizations may apply, as long as there is demonstrable benefit to the US healthcare system and US efforts in the area of patient-centered research. Organizations may submit multiple funding applications. Individuals may not apply.Download Full Announcement