Key Dates

  • LOI Status Notification:
    March 5, 2024
  • Application Deadline:
    May 7, 2024; 5 pm (ET)
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With this PCORI Funding Announcement (PFA), PCORI aims to fund studies that address high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER).

For the 2024 Methods PFA, PCORI has identified the following areas as programmatic priorities that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies:

  • Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Clinical Research
  • Methods to Improve Study Design
  • Methods to Support Data Research Networks
  • Methods Related to Ethical and Human Subjects Protections Issues in CER

Update for the 2024 Methods PFA

Beginning in Cycle 1 2024, PCORI has changed the title of this PFA from “Improving Methods for Conducting PCOR” to “Improving Methods for Conducting Patient-Centered CER.” This reflects recent changes to PCORI naming conventions. There are no substantive changes to the PFA related to this title change.

Standing 2024 Methods PFA

Continuing the practice started with Cycle 1 2022, PCORI posts all submission materials for the Methods PFAs and open PCORI Online for the Letter of Intent (LOI) phase of application submission at the start of the cycle year (i.e., cycles 1-3 of any given year). In addition to the PFAs, the Submission Instructions, applicant templates and resources, and cycle deadlines will also be posted on PCORI’s website and available in PCORI Online. Applicants may submit an LOI for any of the available cycles up until the LOI deadline for that cycle. PCORI will strive to make only necessary administrative updates to the Submission Instructions and applicant templates throughout the cycle year.

To maintain responsiveness to health research needs and stakeholder interests, PCORI may revise the Methods PFA details and address policy changes. Announcements of any updates and any revised documents will be posted on PCORI’s website no later than four weeks before each cycle’s LOI deadline. PCORI will also clearly indicate on the PFA webpage if no changes have been made since the prior cycle posting.

View Key Dates for Cycle 1 below. Click here for Key Dates for Cycle 2 and Cycle 3.
Download Full Announcement

Key Dates

Online System Opens
January 9, 2024
Applicant Town Hall
View Event
Letter of Intent Deadline
February 6, 2024, by 5 pm (ET)
Letter of Intent Status Notification
March 5, 2024
Application Deadline
May 7, 2024, by 5 pm (ET)
Merit Review
July 2024
Awards Announced
November 2024
Earliest Start Date
April 2025

Funds and Project Period

Funds Available Up To
$12 million
Total Direct Costs
Up to $750,000
Maximum Project Period
Up to 3 years

To Apply for This Opportunity

  1. Read the full funding announcement
  2. Follow the process outlined in the Submission Instructions
  3. Submit a Letter of Intent
  4. Submit an application (if invited)

Applicant Resources

Write Your LOI

Submit Your Application

Required Application Templates

If you are Resubmitting Your Application

Additional Applicant Resources

Cycle 2 2024 Key Dates

Online System OpensMay 7, 2024
Letter of Intent (LOI) DeadlineJune 4, 2024, 5 pm (ET)
LOI Status NotificationJuly 2, 2024
Application DeadlineSept. 4, 2024, 5 pm (ET)

Cycle 3 2024 Key Dates

Online System OpensSept. 4, 2024
Letter of Intent (LOI) DeadlineOct. 1, 2024, 5 pm (ET)
LOI Status NotificationOct. 29, 2024
Application DeadlineJan. 14, 2025, 5 pm (ET)


Award Types