Letters of Intent are due Tuesday, June 1, 2021, by 5:00 p.m. ET. Full applications will be due Tuesday, August 31, 2021, by 5:00 p.m. ET. |
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With this PCORI Funding Announcement (PFA), PCORI aims to fund studies that address high-priority methodological gaps in patient-centered outcomes research (PCOR) and clinical comparative effectiveness research (CER).
PCORI seeks to fund projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by PCOR/CER studies.
For the Cycle 1 2021 Methods PFA, PCORI has identified the following areas as programmatic priorities:
- Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Clinical Research
- Methods to Improve Study Design
- Methods to Support Data Research Networks
- Methods Related to Ethical and Human Subjects Protections Issues in PCOR/CER
The programmatic priority for artificial intelligence and machine learning replaced the priority for "Methods to Improve the Use of Natural Language Processing (NLP)" as of Cycle 3 2020. This change signals PCORI’s broader interest in funding methodological research that seeks to improve how massive amounts of data from a variety of sources can be: (1) appropriately analyzed and integrated into clinical care and health care delivery systems, and (2) facilitate population health models and social determinants of health analyses. Proposals should address mechanisms seeking to improve equitable, inclusive data collection and aggregation. NLP-related proposals will still be considered.
PCORI Improves Funding Opportunities and Application Process for 2021 Learn more about the PFAs that are opening in 2021, as well as changes to the application process and the pilot of a deferral option for applicants to the Broad and Methods PFAs. |
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To Apply for this Opportunity
- Read the full funding announcement
- Follow the process outlined in the Submission Instructions
- Submit a Letter of Intent
- Submit an application (if invited)
Applicant Resources
Write Your LOI
- Methods PFA
- Methods Submission Instructions
- Methods Submission Checklist
- Methods LOI Template
- Applicant FAQs
- Methods PFA FAQs
- PCORI Online: Pre-Award User Guide for Research Awards
- Tips for Preparing a Responsive Letter of Intent (LOI)
Submit Your Application
- Methods PFA
- Methods Submission Instructions
- Methods Submission Checklist
- Applicant FAQs
- Methods PFA FAQs
- PCORI Online: Pre-Award User Guide for Research Awards
Required Application Templates
- Methods PI Template
- Methods Key Personnel Template
- Methods Project/Performance Site(s) and Resources Template
- Methods Leadership Plan Template (Only required if proposed project is dual-PI)
- Methods Research Plan Template
- Methodology Standards Checklist
- Methods Milestones Template
- Methods Subcontractor Detailed Budget Template
- Methods Budget Justification Template
- Methods Letters of Support Table
If you are Resubmitting Your Application
Additional Applicant Resources
- PCORI Methodology Report and Standards
- Policy on Submission of Research Contract Applications
- Glossary
- Ambassador Center
- Engagement Rubric
- Engagement in Research
- Budgeting for Engagement Activities
- Compensation Framework
- Cost Principles: Description of Allowable Direct Costs under a PCORI Award
- PCORI Merit Review Criteria
- Standard Contract for Funded Research Projects