Medication-Assisted Treatment (MAT) Delivery for Pregnant Women with Substance Use Disorders Involving Prescription Opioids and/or Heroin -- Cycle 2 2018

Due to the continued concern about the opioid epidemic, the Patient-Centered Outcomes Research Institute (PCORI) is reopening this funding initiative.

PCORI seeks to fund large high-quality studies that respond to the following priority question:

What is the comparative effectiveness of different strategies for providing support or coordination of services for components of medication-assisted treatment (MAT) (induction and/or psychosocial services) to providers who offer office-based opioid treatment (OBOT) to pregnant women, in terms of maternal and neonatal outcomes?

Each proposed comparator must be clearly defined, evidence-based or in clinical use, and be, or be able to be made, widely available. While randomized controlled trials (RCTs) are preferred, well-designed comparative observational studies and natural experiments of established programs with evidence of efficacy may also be proposed.

Applicants should justify their patient populations of interest (e.g., urban, rural, low-income, and/or racial and ethnic minorities). For this PFA, PCORI is particularly interested in proposals that focus on or include urban, low-income, and racial-ethnic minority populations.

Support for providers should address provider barriers such as patient induction (e.g., in an addiction clinic, emergency department, hospital, or at home versus the clinician’s office) and psychosocial services (e.g., different levels of medication management by provider, on-site individual or group counseling, online services, referral). Proposals should have strong endorsement and study participation by patient organizations, professional organizations, payer or purchaser organizations, and other relevant stakeholder groups.